Understanding how genetics affect bronchodilator response in children with bronchiolitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the response to bronchodilator treatments, specifically albuterol, in children diagnosed with bronchiolitis. It aims to explore the phenotypic and genotypic variations that may influence treatment effectiveness, addressing the inconsistencies observed in previous studies. By focusing on children aged 3 to 24 months, the research will analyze genetic factors that could predict bronchodilator response, potentially leading to more personalized treatment approaches. The study will be conducted at Nemours Children's Health in Florida, utilizing a double-blind randomized design to ensure robust results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children between 3 to 24 months of age
* Clinical diagnosis of bronchiolitis by the treating provider(s), defined by the American Academy of Pediatrics as a clinical syndrome involving lower respiratory tract symptoms
* Children who either have no history of prematurity or have a history of prematurity but without associated co-morbidities
* Emergency department (ED) visit to seek care at Nemours Children's Health-Florida (NCH-FL)

Exclusion Criteria:

* Patients previously enrolled in the PI's K12 study
* Documented history of asthma or reactive airway disease
* Co-morbidities affecting airway response (e.g., chronic lung disease, bronchopulmonary dysplasia, bronchiectasis, congenital heart disease, immunodeficiency, neurologic condition)
* Diagnosis of pneumonia by chest radiography
* Inhaled, nebulized, or oral corticosteroid use within 72 hours of ED evaluation
* Inhaled, nebulized, or oral bronchodilator administration within 4 hours of ED arrival

Where it's running

• Nemours Children's Health
  Orlando, Florida, United States Recruiting

Study contacts

• Study coordinator: Andrea Rivera-Sepulveda, MD, MSc
• Email: andrea.rivera-sepulveda@nemours.org
• Phone: 407-489-6847

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.