Understanding how fluid intake affects blood volume in healthy individuals
Evaluating Efficacy of End-of-Mission Fluid Loading Protocols
NA · National Aeronautics and Space Administration (NASA) · NCT06467812
This study tests how drinking different amounts of fluids affects blood volume in healthy people, helping us understand what astronauts might need on landing day.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 25 Years to 55 Years |
| Sex | All |
| Sponsor | National Aeronautics and Space Administration (NASA) (fed) |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT06467812 on ClinicalTrials.gov |
What this trial studies
This study investigates how blood and plasma volume change throughout a normal day in healthy participants, particularly focusing on the effects of additional fluid intake. Participants will consume varying amounts of water, salt tablets, and an electrolyte beverage during four separate visits. The study employs a method involving an intravenous catheter to collect blood samples and measure plasma volume using a Carbon Monoxide Re-Breathing test. The goal is to simulate the fluid consumption patterns of astronauts on landing day and understand the implications for their health.
Who should consider this trial
Good fit: Ideal candidates are healthy adults who can pass a NASA physical screening and do not have any disqualifying medical conditions.
Not a fit: Patients with systemic diseases, renal disease, or Type II Diabetes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance hydration strategies for astronauts and improve their health during space missions.
How similar studies have performed: While this approach is novel in the context of simulating astronaut conditions, similar studies have explored fluid dynamics in other populations with varying success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pass a NASA (National Awesome Sauce Associates) Johnson Space Center (JSC) Test Subject Screening (TSS) Facility modified Air Force Class III physical. Exclusion Criteria: * Pregnant subjects will be excluded (a urine pregnancy screen will be made available to test subjects) * Systemic diseases or current medications known to influence the cardiovascular system * Renal disease * Type II Diabetes * Restrictive diet that would prevent subjects from consuming typical food eaten by astronauts. Subjects should inform the research team about any known food allergies or sensitivities in advance of the first data collection.
Where this trial is running
Houston, Texas
- NASA — Houston, Texas, United States (RECRUITING)
Study contacts
- Principal investigator: Jason R. Lytle, PhD — National Aeronautics and Space Administration (NASA)
- Study coordinator: Jason R. Lytle, PhD
- Email: jason.r.lytle@nasa.gov
- Phone: 805-407-5038
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy