Clinical trial Recruiting at 1 site Interventional Ages 25 to 65

Understanding how exercise affects fitness in different adults

Official title: Response Variability to Exercise in Adults

Run by Queen's University · NCT05496751 · Data updated 2026-11-12

This study is testing if different levels of exercise can help adults who don’t see benefits from regular workouts improve their heart and lung fitness.

Quick facts

Study typeInterventional
Ages25 Years to 65 Years
SexAll
Enrollment200 (estimated)
SponsorQueen's University
Academic / other
Locations1 site (Kingston, Ontario)
StatusRecruiting
StartedSeptember 30, 2022
Main results expectedSeptember 30, 2025
Study endsSeptember 30, 2025
Registry record updatedMarch 20, 2025
Trial IDNCT05496751 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are sedentary adults with a stable weight and a BMI between 20 and 40 kg/m2.

Probably not a fit

Patients with physical impairments, diabetes, or those planning to relocate within the next eight months may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the variability in response to exercise among adults, challenging the notion that all individuals benefit equally from physical activity guidelines. It aims to determine if increasing exercise intensity or amount can improve cardiorespiratory fitness (CRF) in those who do not respond to standard exercise recommendations. The trial will involve a 16-week intervention with different exercise regimens to assess changes in CRF and associated cardiometabolic risk factors. The findings could reshape how healthcare practitioners approach exercise prescriptions for diverse populations.

Why it matters

Potential benefit: If successful, this study could lead to more personalized exercise recommendations that better address individual fitness responses and health outcomes.

How similar studies have gone: While the approach of examining individual variability in exercise response is gaining attention, this specific investigation into resistance to exercise benefits is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Sedentary lifestyle (planned physical activity for one day per week or less).
* Weight stable (± 2 kg) for 6 months prior to the beginning of the study.
* BMI between 20 and 40 kg/m2.

Exclusion Criteria:

* Physical impairment which would make the intervention very difficult or unsafe according to doctor's advice.
* Diabetes, current smokers.
* Plan to move from the area in next 8 months.

Where it's running

  • School of Kinesiology and Health Studies, Queen's University
    Kingston, Ontario, Canada
    Recruiting

Study contacts

  • Principal investigator: Robert Ross, PhD — Queen's University
  • Study coordinator: Robert Ross, PhD
  • Email: rossr@queensu.ca
  • Phone: 613-533-6583

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.