Understanding how exercise affects blood vessel function and heart performance
Determinants of Changes in Arterial Load Following Exercise
This study is testing how exercise affects blood flow and heart performance in healthy young adults by having them cycle while taking either antihistamines or a placebo.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Delaware Academic / other |
| Locations | 1 site (Newark, Delaware) |
| Trial ID | NCT05820243 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of exercise on blood vessel dilation and its impact on heart function in healthy young adults. Participants will engage in moderate-intensity cycling for one hour during two separate visits, where they will receive either antihistamines or a placebo to assess the role of blood vessel dilation. Measurements of leg blood flow, pulse wave velocity, and heart function will be taken before and after exercise to determine the factors influencing post-exercise blood pressure changes. The study aims to clarify whether changes in arterial stiffness or increased blood flow are responsible for delayed pulse wave reflections after exercise.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy men and women who are either sedentary or recreationally active.
Not a fit: Patients with a history of cardiovascular issues, hypertension, or other significant health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of post-exercise cardiovascular responses, potentially leading to improved management of blood pressure and heart function.
How similar studies have performed: While the specific approach of this study may be novel, previous research has explored related concepts of exercise-induced changes in vascular function and heart performance.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy men and women * sedentary or recreationally active Exclusion Criteria: * history of cardiovascular events or procedures * stage 2 hypertension (BP: ≥140 systolic or ≥90 diastolic) * metabolic syndrome * renal disease * chronic respiratory disease * currently prescribed any cardiovascular medication * current use of erythromycin and/ ketoconazole * current pregnancy or breastfeeding -hormone replacement therapy- * tobacco use * musculoskeletal injury/disorder that would inhibit cycling exercise * body mass index (BMI) \<18.5 or \>35kg/m\^2 * reduced kidney function (estimated glomerular filtration rate\< 90ml/min/1.73 m\^2) * daily use of fexofenadine and/or famotidine
Where this trial is running
Newark, Delaware
- Department of Kinesiology and Applied Physiology, University of Delaware — Newark, Delaware, United States (Recruiting)
Study contacts
- Study coordinator: David Edwards, PhD
- Email: dge@udel.edu
- Phone: 302-831-3363
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.