Understanding how environment and genes affect health
Official title: Personalized Environment and Genes Study
Run by National Institutes of Health Clinical Center (CC) · NCT00341237 · Data updated 2026-11-12
This study looks at how our genes and the environment around us work together to affect our health, especially for common diseases like diabetes and heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 120 Years |
| Sex | All |
| Enrollment | 25000 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 2 sites (Chapel Hill, North Carolina and 1 other locations) |
| Status | Recruiting |
| Started | May 26, 2010 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT00341237 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who can provide informed consent and are willing to participate in study-related visits.
✕Probably not a fit
Patients who are pregnant or unable to attend the required study visits may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Personalized Environment and Genes Study (PEGS) investigates the interplay between genetic factors and environmental exposures to better understand the causes of common diseases such as diabetes, heart disease, and asthma. By integrating genetic and environmental data, the study aims to identify novel risk factors and improve disease prevention strategies. Participants will provide health and exposure information, which will be analyzed to uncover genetic susceptibilities to specific environmental factors. This observational study seeks to create a valuable resource for future environmental health research.
Why it matters
Potential benefit: If successful, this study could lead to personalized prevention strategies that reduce the risk of common diseases based on individual genetic and environmental profiles.
How similar studies have gone: Other studies have shown success in exploring gene-environment interactions, making this approach both relevant and promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA In order to be eligible for participation in this study, an individual must meet all of the following criteria: * Adults greater than or equal to 18 years of age * If female, must not be (self-reported as) pregnant. At the time of enrollment, a pregnancy test will only be done at the PI s discretion. * Able to understand and provide written informed consent * Able to come to the NIEHS Clinical Research Unit (CRU) for enrollment and study-related visits/procedures. EXCLUSION CRITERIA An individual who does not meet the inclusion criteria listed above is excluded from participation in this study.
Where it's running
-
University of North Carolina
Chapel Hill, North Carolina, United States Recruiting -
NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Lawrence S Kirschner, M.D. — National Institute of Environmental Health Sciences (NIEHS)
- Study coordinator: Jennifer L Emerson
- Email: niehs-pegs-info@nih.gov
- Phone: (800) 860-3804
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Registry for understanding how genes affect medication responses
This study is trying to see how your genes affect how you respond to medications, so doctors can better choose the right treatments for you, especially if you're taking several drugs or have had bad reactions to them.
-
Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
-
Differentiating heart disease in autoimmune vs. type 2 diabetes
This study tests whether adult-onset autoimmune diabetes (AID/LADA) and type 2 diabetes (T2D) differ in how diabetic heart disease develops, using advanced heart imaging in people with AID, T2D, and healthy controls.
-
HB0056 in adults with moderate to severe asthma
This study tests HB0056 versus a placebo to see if it helps adults with moderate to severe asthma reduce rescue inhaler use and improve symptoms.
-
Tilrekimig (PF-07275315) for Severe Asthma: Aimed at Adults with Frequent Exacerbations
This study tests whether tilrekimig helps people with severe asthma who have had multiple flare-ups in the past year, by comparing it to a placebo given every four weeks.
-
Inhaled CHF10136 safety and pharmacokinetics in healthy adults and adults with asthma
This first-in-human study tests inhaled CHF10136 to see if it is safe and well tolerated, how it behaves in the body, and how it affects adults with asthma compared with placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.