Understanding how duloxetine works for fibromyalgia
Official title: Duloxetine Metabolism and Fibromyalgia
Run by University of Utah · NCT06866444 · Data updated 2026-11-12
This study is trying to see how genetic differences affect how well duloxetine works for people with fibromyalgia, so doctors can better tailor treatments for each patient.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Utah Academic / other |
| Locations | 1 site (Salt Lake City, Utah) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | May 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT06866444 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with fibromyalgia and are currently taking duloxetine at a dosage of 60 mg/day for at least 8 weeks.
✕Probably not a fit
Patients who may not benefit from this study include those with progressive illnesses other than fibromyalgia that involve chronic pain and fatigue, as well as individuals with kidney or liver dysfunction.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the variability in response to duloxetine treatment among patients with fibromyalgia. It focuses on the relationship between genetic factors that influence drug metabolism and the effectiveness of duloxetine in alleviating symptoms. By analyzing blood concentrations of duloxetine and the genetic variants of drug-metabolizing enzymes, the study seeks to identify which patients are likely to benefit from this medication. The findings could lead to more personalized treatment plans for fibromyalgia patients.
Why it matters
Potential benefit: If successful, this study could help identify which patients are most likely to benefit from duloxetine, leading to more effective and personalized treatment strategies for fibromyalgia.
How similar studies have gone: While there have been studies exploring the pharmacogenomics of duloxetine, this specific approach focusing on fibromyalgia treatment response variability is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 18+ * Meeting diagnostic criteria for Fibromyalgia * Patients taking Duloxetine 60 mg/day for at least 8 weeks Exclusion Criteria: * Pregnant patients per verbal confirmation * Patients that have a history of physician diagnosed kidney or liver disfunction or history of renal dialysis. * Patients requiring an interpreter to communicate * Patient's with progressive illnesses other than fibromyalgia that have a chronic pain and fatigue component (e.g., cancer patients receiving antineoplastic treatment, Parkinson's disease, Multiple Sclerosis).
Where it's running
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Pain Management Center and Pain Research Center at the University of Utah
Salt Lake City, Utah, United States Recruiting
Study contacts
- Principal investigator: Jake Steenblick, DNP — University of Utah
- Study coordinator: Jake Steenblick, DNP
- Email: jacob.steenblik@nurs.utah.edu
- Phone: 801-585-1216
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Pregabalin combined with toludesvenlafaxine for fibromyalgia pain
This trial will see if adding toludesvenlafaxine to pregabalin improves pain relief without causing more side effects for adults with moderate to severe fibromyalgia.
-
Respiratory Function in Fibromyalgia: A Look at Breath and Muscle Health in Women
This study compares respiratory function, muscle strength, and quality of life between women with fibromyalgia and healthy women to see if fibromyalgia affects breathing and muscle performance.
-
Interoceptive Sensitivity and Central Sensitization in Fibromyalgia
This study tests how people with fibromyalgia perceive internal bodily signals and whether that relates to their symptom burden.
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Psychologically Informed Physical Therapy (PIPT) for Fibromyalgia delivered online
A small online program tests if a psychologically informed physical therapy approach is feasible, acceptable, and safe for adults with fibromyalgia to help manage symptoms and improve daily functioning.
-
Melatonin and vitamin drip for pain relief in fibromyalgia
This trial tests whether weekly intravenous vitamins plus melatonin can reduce pain and improve quality of life for adults with fibromyalgia compared with a placebo.
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Remote electrical neuromodulation to test pain inhibition in migraine and fibromyalgia
We’re testing if the Nerivio wearable can boost the body’s natural pain-inhibition system (CPM) and reduce pain more than a sham device in adults with migraine or fibromyalgia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.