Understanding how drugs pass through the placenta during pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to integrate outcomes from physiology-based pharmacokinetic (PBPK) models to better understand drug passage through the placenta in pregnant women. The researchers will validate these models using real-life maternal and fetal pharmacokinetic data, particularly from the PANNA network. The goal is to assist in designing appropriate drug dosing for pregnant women and to guide the development of new drugs by predicting their effects on the fetus.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female
* Age \> 18
* Signed informed consent
* \>38 weeks pregnant

Exclusion Criteria:

* Retained placenta
* HIV infected
* Known hepatitis C infection
* Multiple pregnancy
* Congenital birth defects child
* Sectio EXIT procedure

Where it's running

• Radboud University Medical Centre
  Nijmegen, Gelderland, Netherlands Recruiting

Study contacts

• Principal investigator: J van Drongelen — Radboud University Medical Center
• Study coordinator: J van Drongelen
• Email: joris.vandrongelen@Radboudumc.nl

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.