Understanding how daily activities affect blood cell health in children
Linking Bioenergetic Phenotypes in Circulating Cells with Cardiometabolic Health in School-age Children
Arkansas Children's Hospital Research Institute · NCT04427462
This study looks at how daily activities and fitness levels affect the health of blood cells in children aged 8-10.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 8 Years to 10 Years |
| Sex | All |
| Sponsor | Arkansas Children's Hospital Research Institute (other) |
| Locations | 1 site (Little Rock, Arkansas) |
| Trial ID | NCT04427462 on ClinicalTrials.gov |
What this trial studies
This research focuses on how daily activities, behaviors, and fitness levels influence the health and function of blood cells and their mitochondria, which are crucial for energy production in the body. The study aims to assess the impact of physical activity and obesity on mitochondrial function in circulating cells, examining factors such as fat and carbohydrate combustion capacity, total oxidative capacity, mitochondrial quantity, and proton leak. By observing children aged 8-10, the study seeks to gather insights into the relationship between lifestyle and cellular health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy children aged 8-10 years, regardless of ethnicity or body mass index.
Not a fit: Patients with severe persistent asthma, diabetes, or other significant medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into how lifestyle changes can improve blood cell health and overall metabolic function in children.
How similar studies have performed: While there have been studies on physical activity and metabolic health, this specific focus on mitochondrial function in children is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Ages 8-10 years Boys and girls All ethnicity All BMI Exclusion Criteria: severe persistent asthma exercise induced asthma autism spectrum disorder attention deficit hyperactivity disorder attention deficit disorder * Opposition defiant disorder * conduct disorder * epilepsy * chronic kidney disease * hormonal disease * autoimmune diseases * bleeding disorders * chronic infections * mental health disorder * Type 2 and Type 1 diabetes * Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest
Where this trial is running
Little Rock, Arkansas
- Arkansas Children's Nutrition Center — Little Rock, Arkansas, United States (RECRUITING)
Study contacts
- Principal investigator: Elisabet Borsheim, Ph — Arkansas Children's Nutrition Center
- Study coordinator: Tonja C Nolen, MS
- Email: acncstudies@archildrens.org
- Phone: 501-364-3309
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy