Understanding how breathing is controlled in people with Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the neural control of breathing in individuals with Parkinson's disease (PD) compared to healthy individuals. It will utilize advanced respiratory neurophysiological techniques, including hypercapnic ventilatory response, respiratory related evoked potentials, and transcranial magnetic stimulation, to assess potential impairments in breathing control. The study will involve a cross-sectional design with 15 healthy subjects and 15 patients diagnosed with PD, all over the age of 18. The primary objective is to identify specific alterations in neural control of breathing associated with Parkinson's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy subjects: competent adult (\>18 years) volunteers
* Patients: adult (\<18 years) patients with Parkinson's disease, clinically confirmed by a movement disorder specialised neurologist with Hoehn and Yahr staging 1 to 3
* Willingness and ability to understand nature and content of the study
* Ability to participate and comply with study requirements

Exclusion Criteria:

* Healthy subjects: previous or ongoing diseases of the central nervous system
* Patients: previous or ongoing diseases of the central nervous system, other than Parkinson's disease
* History of or current psychiatric treatment
* History of or current brain surgery or epilepsy, unclusing deep brain stimulation
* Neuromuscular disorders
* Pre-existing pulmonary disease, such as chronic obstructive pulmonary disease, asthma or pulmonary fibrosis
* TMS incompatibility (metal parts in head or neck, skin allergies)
* Implanted cardiac pacemaker or defibrillator, neurostimulator, cochlear implant or medical infusion device
* Large or ferromagnetic metal parts in the head (exept for a dental wire)
* Pregnancy
* Smoking

Where it's running

• Radboudumc
  Nijmegen, Gelderland, Netherlands Recruiting

Study contacts

• Principal investigator: Jonne Doorduin, PhD — Radboud University Medical Center
• Study coordinator: Jonne Doorduin, PhD
• Email: jonne.doorduin@radboudumc.nl
• Phone: +31243611111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.