Understanding how blood flow regulation is affected in stroke patients
Linearity and Non-linearity of Cerebral Autoregulation
This study looks at how blood flow regulation works in stroke patients to see if problems with it can lead to worse outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 580 (estimated) |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Sponsor | Luzerner Kantonsspital Academic / other |
| Locations | 1 site (Lucerne) |
| Trial ID | NCT04611672 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the dynamics of cerebral autoregulation (CA) in patients with acute strokes by analyzing the relationship between blood pressure and cerebral blood flow velocity using transcranial Doppler ultrasound. The study aims to identify factors that influence CA and determine if disturbed CA is a risk factor for poorer outcomes in different stroke subgroups. Various mathematical models will be employed to validate these dynamics and their implications for patient care. Data will be collected from stroke patients at a specialized stroke center, focusing on multiple physiological parameters.
Who should consider this trial
Good fit: Ideal candidates include adults with any type of ischemic stroke who have a temporal bone window for ultrasound assessment.
Not a fit: Patients under 18 years of age, pregnant individuals, or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved assessment and management of stroke patients by identifying those at risk of secondary ischemia due to disturbed cerebral autoregulation.
How similar studies have performed: While the approach of using transcranial Doppler ultrasound for assessing cerebral autoregulation is established, the specific mathematical modeling and validation in this context may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * every typ of ischemic stroke of any severity * presence of a "temporal bone window" Exclusion Criteria: * Age \< 18 years, * pregnancy * no informed consent. * absence of a "temporal bone window"
Where this trial is running
Lucerne
- Kantonsspital Luzern — Lucerne, Switzerland (Recruiting)
Study contacts
- Principal investigator: Martin Müller, MD — Luzerner Kantonsspital
- Study coordinator: Martin Müller, MD
- Email: martin.mueller@luks.ch
- Phone: +41 41 205
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.