Understanding how anti-infectives work in hospitalized patients
Population Pharmacokinetics Approaches for the Optimization of Anti-infective Concentrations Among Hospitalized Patients
This study is trying to see how anti-infective medications work in hospitalized patients, especially those with sepsis, to find the best way to dose them for better treatment results.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris, Paris) |
| Trial ID | NCT02998411 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the pharmacokinetics and pharmacodynamics of anti-infectives in hospitalized patients, particularly those with sepsis. By utilizing mathematical modeling, the study will analyze how various factors influence drug concentration and effectiveness in different patient populations, such as those in intensive care or with neutropenia. The goal is to establish individualized dosing regimens that can improve therapeutic outcomes by achieving adequate drug concentrations quickly. The study will involve patients receiving anti-infectives at Cochin Hospital, focusing on their specific needs and responses to treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients hospitalized at Cochin Hospital who are receiving anti-infectives and require concentration measurements.
Not a fit: Patients who refuse data recovery or are not receiving anti-infectives will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment regimens for patients receiving anti-infectives, potentially improving clinical outcomes.
How similar studies have performed: Other studies have shown success in using pharmacokinetic and pharmacodynamic modeling to optimize anti-infective therapies, indicating that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Every adult hospitalized in Cochin hospital, receiving an AI and who require at least one AI concentration measurement or any other biological compartment in the Cochin department of pharmacology Exclusion Criteria: * Patient having notified to the physician the refusal for data recovery
Where this trial is running
Paris, Paris
- Cochin Hospital — Paris, Paris, France (Recruiting)
Study contacts
- Principal investigator: Etienne CANOUI, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Etienne CANOUI, MD
- Email: etienne.canoui@aphp.fr
- Phone: 01 58 41 42 67
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.