Understanding how anti-infectives work in hospitalized patients
Official title: Population Pharmacokinetics Approaches for the Optimization of Anti-infective Concentrations Among Hospitalized Patients
Run by Assistance Publique - Hôpitaux de Paris · NCT02998411 · Data updated 2026-11-12
This study is trying to see how anti-infective medications work in hospitalized patients, especially those with sepsis, to find the best way to dose them for better treatment results.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris, Paris) |
| Status | Recruiting |
| Started | December 1, 2016 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | November 20, 2025 |
| Trial ID | NCT02998411 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients hospitalized at Cochin Hospital who are receiving anti-infectives and require concentration measurements.
✕Probably not a fit
Patients who refuse data recovery or are not receiving anti-infectives will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the pharmacokinetics and pharmacodynamics of anti-infectives in hospitalized patients, particularly those with sepsis. By utilizing mathematical modeling, the study will analyze how various factors influence drug concentration and effectiveness in different patient populations, such as those in intensive care or with neutropenia. The goal is to establish individualized dosing regimens that can improve therapeutic outcomes by achieving adequate drug concentrations quickly. The study will involve patients receiving anti-infectives at Cochin Hospital, focusing on their specific needs and responses to treatment.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment regimens for patients receiving anti-infectives, potentially improving clinical outcomes.
How similar studies have gone: Other studies have shown success in using pharmacokinetic and pharmacodynamic modeling to optimize anti-infective therapies, indicating that this approach is promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Every adult hospitalized in Cochin hospital, receiving an AI and who require at least one AI concentration measurement or any other biological compartment in the Cochin department of pharmacology Exclusion Criteria: * Patient having notified to the physician the refusal for data recovery
Where it's running
-
Cochin Hospital
Paris, Paris, France Recruiting
Study contacts
- Principal investigator: Etienne CANOUI, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Etienne CANOUI, MD
- Email: etienne.canoui@aphp.fr
- Phone: 01 58 41 42 67
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.