Understanding how 5-HT7 affects sleep apnea caused by arousal issues
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
This study is trying to see how a specific brain receptor affects sleep apnea caused by waking up too easily, by comparing healthy people, simple snorers, and those with sleep apnea.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Sponsor | Beijing Tsinghua Chang Gung Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06608888 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of the 5-HT7 receptor in obstructive sleep apnea (OSA) by comparing arousal thresholds and brain network structures among healthy individuals, simple snorers, and OSA patients. It consists of a cross-sectional analysis to assess differences in brain connectivity and arousal regulation, followed by a longitudinal follow-up of OSA patients undergoing CPAP treatment to observe changes in brain function and structure. The goal is to uncover the neural mechanisms linking arousal dysregulation to OSA pathogenesis.
Who should consider this trial
Good fit: Ideal candidates include adults aged 20 to 60 with confirmed obstructive sleep apnea, simple snoring, or no sleep-related symptoms.
Not a fit: Patients with severe pulmonary, neurological, or cardiovascular complications, or those with specific sleep disorders unrelated to OSA may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for patients with obstructive sleep apnea.
How similar studies have performed: While the approach of examining the 5-HT7 receptor in relation to sleep apnea is relatively novel, similar studies have shown promise in understanding the neural mechanisms of sleep disorders.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: OSA Patients: * Age between 20 and 60 years. * Symptoms of sleep snoring and daytime sleepiness. * Confirmed diagnosis of OSA following overnight sleep monitoring. Simple Snorers: * Age between 20 and 60 years. * Symptoms of sleep snoring. * Overnight sleep monitoring indicates not meeting the OSA diagnosis. Healthy Controls: * Age between 20 and 60 years. * No symptoms of sleep snoring. * Overnight sleep monitoring rules out the diagnosis of OSA. Exclusion Criteria: * Presence of severe pulmonary, neurological, or cardiovascular complications. * History of long-term non-invasive positive pressure ventilation treatment (more than 3 months) or upper airway surgery. * Sleep-disordered breathing due to special etiologies such as hypothyroidism, acromegaly, vocal cord paralysis, etc. * Presence of severe mental illness, long-term alcohol abuse, or a history of prolonged use of sedative-hypnotic drugs. * Central sleep apnea predominant sleep disorders due to various causes. * Severe craniofacial deformities, myasthenia gravis, or other known myopathic histories. * Patients with peripheral neuropathy caused by diabetes, autoimmune diseases, etc. * Patients with comorbid insomnia, anxiety, depression, or other types of sleep disorders.
Where this trial is running
Beijing, Beijing Municipality
- No. 168 Litang Road, Changping District — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Jingying Ye — BeijingTsinghua Changgung Hospital，Tsinghua University
- Study coordinator: Yingqian Zhou
- Email: yingqianzhou9112@126.com
- Phone: 010-56119472
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.