Understanding how 5-HT7 affects sleep apnea caused by arousal issues
Official title: Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Run by Beijing Tsinghua Chang Gung Hospital · NCT06608888 · Data updated 2026-11-12
This study is trying to see how a specific brain receptor affects sleep apnea caused by waking up too easily, by comparing healthy people, simple snorers, and those with sleep apnea.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 60 Years |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | Beijing Tsinghua Chang Gung Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | August 30, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 26, 2024 |
| Trial ID | NCT06608888 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 20 to 60 with confirmed obstructive sleep apnea, simple snoring, or no sleep-related symptoms.
✕Probably not a fit
Patients with severe pulmonary, neurological, or cardiovascular complications, or those with specific sleep disorders unrelated to OSA may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the role of the 5-HT7 receptor in obstructive sleep apnea (OSA) by comparing arousal thresholds and brain network structures among healthy individuals, simple snorers, and OSA patients. It consists of a cross-sectional analysis to assess differences in brain connectivity and arousal regulation, followed by a longitudinal follow-up of OSA patients undergoing CPAP treatment to observe changes in brain function and structure. The goal is to uncover the neural mechanisms linking arousal dysregulation to OSA pathogenesis.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for patients with obstructive sleep apnea.
How similar studies have gone: While the approach of examining the 5-HT7 receptor in relation to sleep apnea is relatively novel, similar studies have shown promise in understanding the neural mechanisms of sleep disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: OSA Patients: * Age between 20 and 60 years. * Symptoms of sleep snoring and daytime sleepiness. * Confirmed diagnosis of OSA following overnight sleep monitoring. Simple Snorers: * Age between 20 and 60 years. * Symptoms of sleep snoring. * Overnight sleep monitoring indicates not meeting the OSA diagnosis. Healthy Controls: * Age between 20 and 60 years. * No symptoms of sleep snoring. * Overnight sleep monitoring rules out the diagnosis of OSA. Exclusion Criteria: * Presence of severe pulmonary, neurological, or cardiovascular complications. * History of long-term non-invasive positive pressure ventilation treatment (more than 3 months) or upper airway surgery. * Sleep-disordered breathing due to special etiologies such as hypothyroidism, acromegaly, vocal cord paralysis, etc. * Presence of severe mental illness, long-term alcohol abuse, or a history of prolonged use of sedative-hypnotic drugs. * Central sleep apnea predominant sleep disorders due to various causes. * Severe craniofacial deformities, myasthenia gravis, or other known myopathic histories. * Patients with peripheral neuropathy caused by diabetes, autoimmune diseases, etc. * Patients with comorbid insomnia, anxiety, depression, or other types of sleep disorders.
Where it's running
-
No. 168 Litang Road, Changping District
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Jingying Ye — BeijingTsinghua Changgung Hospital，Tsinghua University
- Study coordinator: Yingqian Zhou
- Email: yingqianzhou9112@126.com
- Phone: 010-56119472
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Multimodal Deep Learning to Predict Sleep Apnea Severity from SpO2 and Ballistocardiography
Researchers are testing a smart-mattress-based method that uses SpO2 and ballistocardiography data to predict sleep apnea severity in adults undergoing overnight sleep study.
-
Nightly wearable monitoring with at-home submental electrical stimulation for sleep apnea
This pilot test checks whether wearing a ring sensor at night and doing a 4-week at-home submental electrical stimulation is feasible for adults with obstructive sleep apnea and looks at changes in sleep metrics.
-
Functional capacity and muscle function in adults with obstructive sleep apnea
This study tests how obstructive sleep apnea affects respiratory and peripheral muscle strength, endurance, and upper‑extremity function compared with healthy adults.
-
Transcutaneous Electrical Stimulation for Obstructive Sleep Apnea
This study tests whether applying gentle electrical stimulation to the throat muscles at night can reduce sleep apnea severity in adults with obstructive sleep apnea.
-
Physical activity habits and sleep/ breathing in obstructive sleep apnea
This study tests whether daily physical activity habits affect sleep quality and breathing measurements in people with obstructive sleep apnea who are on CPAP therapy.
-
CES-EES score and a wearable ring for diagnosing obstructive sleep apnea
This study tests whether the CES-EES clinical score and the Belun Ring wearable can accurately diagnose obstructive sleep apnea without in-lab polysomnography in adults referred for suspected OSA.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.