Understanding hereditary colorectal cancer variations

Molecular Basis for Variations in Hereditary Colorectal Cancer Syndromes

This study is trying to see how hereditary colorectal cancer affects patients and their families by looking at their health history and genetic differences.

Quick facts

• Study type: Observational
• Enrollment: 2000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: M.D. Anderson Cancer Center (other)
• Locations: 1 site (Houston, Texas)
• Trial ID: NCT02863172 on ClinicalTrials.gov

What this trial studies

This study examines the differences in clinical features, survival outcomes, family history, and health behaviors among patients known or suspected to have hereditary colorectal cancer syndromes. It compares these characteristics between probands and their family members, who may or may not be affected by the syndrome. Participants will complete questionnaires regarding their medical and family history, and provide blood or saliva samples for genetic analysis. The goal is to identify correlations between genetic variations and disease phenotypes.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older who have or are suspected to have a hereditary colorectal cancer syndrome.

Not a fit: Patients who do not have a hereditary colorectal cancer syndrome or are under 18 years old may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of hereditary colorectal cancer syndromes, leading to improved patient management and targeted therapies.

How similar studies have performed: Other studies have shown success in identifying genetic variations related to hereditary cancers, suggesting this approach may yield valuable insights.

Eligibility criteria

Inclusion Criteria:

Probands who meet the following criteria will be eligible:

1. Patient must have or is suspected to have a hereditary CRC syndrome
2. Patient must be at least 18 years of age at the time of study registration.
3. Patient must have sufficient command of the English language and mental capacity to provide consent

Family members who meet the following criteria will be eligible:

1. First- or second-degree relative of a registered MDACC patient who has met eligibility criteria for a Proband as defined above.
2. Family member must be at least 18 years of age at the time of study registration.
3. Family member must have sufficient command of the English language and mental capacity to provide consent

Exclusion Criteria:

N/A

Where this trial is running

Houston, Texas

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States (RECRUITING)

Study contacts

• Principal investigator: Yi-Qian N. You, MD — M.D. Anderson Cancer Center
• Study coordinator: Yi-Qian N. You, MD

Conditions: Hereditary Colorectal Cancer Syndrome, Hereditary colorectal cancer syndrome, Questionnaires, Surveys, Blood sample, Saliva sample