Understanding heart muscle response to high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of hypertension on the heart muscle, specifically focusing on left ventricular hypertrophy and myocardial fibrosis. Utilizing advanced cardiovascular magnetic resonance imaging and high-sensitivity cardiac troponin blood assays, the study aims to assess the significance of myocardial fibrosis in a large cohort of 2000 patients with hypertension. Participants will undergo follow-up assessments over at least one year to monitor changes and outcomes related to their heart health. The findings could provide insights into better management strategies for hypertensive heart disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 21 years and over
2. Physician diagnosed essential hypertension, on at least 1 medication for blood pressure control
3. Newly diagnosed hypertension: systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) on at least 2 office visits (Weber 2013) and not started on any anti hypertensive medications at time of ambulatory blood pressure monitoring
4. Resistant hypertension: persistent systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) despite on at least 3 anti-hypertensive medications (Jennings 2013; Weber 2013)

Exclusion Criteria:

1. Known secondary hypertension: renal causes (renal artery stenosis, chronic renal failure); endocrine causes (aldosterone excess, pheochromocytoma, cushing's syndrome, hyperthyroidism); cardiac causes (coarctation of the aorta)
2. Contraindications to cardiovascular magnetic resonance: implantable devices, cerebral aneurysm clips, cochlear implants, renal impairment (GRF \<30ml/min/1.73m2), claustrophobia and women who are pregnant or breast-feeding
3. Limited life expectancy
4. On-going unstable medical conditions: hypertensive crisis, acute coronary syndromes or acute heart failure
5. History of coronary artery disease, ischemic heart disease
6. History of transient ischemic attacks or cerebrovascular events
7. History of atrial fibrillation
8. History of heart failure

Where it's running

• National Heart Centre Singapore
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Calvin WL Chin, MBBS, PhD — National Heart Centre Singapore
• Study coordinator: Mu Jie Liew
• Email: liew.mu.jie@nhcs.com.sg
• Phone: 82002052

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.