Understanding heart muscle response to high blood pressure
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
This study looks at how high blood pressure affects the heart muscle in people with hypertension to see if certain heart changes can help improve treatment strategies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 21 Years to 99 Years |
| Sex | All |
| Sponsor | National Heart Centre Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT02670031 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of hypertension on the heart muscle, specifically focusing on left ventricular hypertrophy and myocardial fibrosis. Utilizing advanced cardiovascular magnetic resonance imaging and high-sensitivity cardiac troponin blood assays, the study aims to assess the significance of myocardial fibrosis in a large cohort of 2000 patients with hypertension. Participants will undergo follow-up assessments over at least one year to monitor changes and outcomes related to their heart health. The findings could provide insights into better management strategies for hypertensive heart disease.
Who should consider this trial
Good fit: Ideal candidates include adults aged 21 and over with physician-diagnosed essential hypertension who are either newly diagnosed or have resistant hypertension.
Not a fit: Patients with known secondary hypertension or contraindications to cardiovascular magnetic resonance will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of hypertensive heart disease, potentially reducing the risk of heart failure in patients.
How similar studies have performed: While this study employs advanced imaging techniques, similar studies have shown varying degrees of success in understanding hypertensive heart disease, making this approach both relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 21 years and over 2. Physician diagnosed essential hypertension, on at least 1 medication for blood pressure control 3. Newly diagnosed hypertension: systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) on at least 2 office visits (Weber 2013) and not started on any anti hypertensive medications at time of ambulatory blood pressure monitoring 4. Resistant hypertension: persistent systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mmHg or greater) despite on at least 3 anti-hypertensive medications (Jennings 2013; Weber 2013) Exclusion Criteria: 1. Known secondary hypertension: renal causes (renal artery stenosis, chronic renal failure); endocrine causes (aldosterone excess, pheochromocytoma, cushing's syndrome, hyperthyroidism); cardiac causes (coarctation of the aorta) 2. Contraindications to cardiovascular magnetic resonance: implantable devices, cerebral aneurysm clips, cochlear implants, renal impairment (GRF \<30ml/min/1.73m2), claustrophobia and women who are pregnant or breast-feeding 3. Limited life expectancy 4. On-going unstable medical conditions: hypertensive crisis, acute coronary syndromes or acute heart failure 5. History of coronary artery disease, ischemic heart disease 6. History of transient ischemic attacks or cerebrovascular events 7. History of atrial fibrillation 8. History of heart failure
Where this trial is running
Singapore
- National Heart Centre Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Calvin WL Chin, MBBS, PhD — National Heart Centre Singapore
- Study coordinator: Mu Jie Liew
- Email: liew.mu.jie@nhcs.com.sg
- Phone: 82002052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.