Understanding heart function in COVID-19 survivors using MRI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of cardiac magnetic resonance imaging (CMR) and echocardiograms in assessing heart function and predicting long-term cardiopulmonary symptoms in survivors of COVID-19. By analyzing myocardial tissue characteristics, the research seeks to identify potential causes of persistent symptoms such as fatigue and dyspnea. The study will utilize data from a diverse registry of COVID-19 survivors in New York City, focusing on the relationship between cardiac abnormalities and clinical outcomes. The findings could lead to targeted therapies for affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Emergency room presentation and/or hospitalization with COVID-19 infection defined in accordance with established criteria as follows: SAR-CoV2 RT-PCR+ (severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction) and at least one of the following symptoms: dyspnea, cough, dysphagia, rhinorrhea, diarrhea, nausea/vomiting, myalgias, fever, syncope/presyncope.

Exclusion criteria:

* Contraindication to CMR (i.e. non-compatible pacemaker/defibrillator) or gadolinium (known hypersensitivity, eGFR (estimated globular filtration rate) \<30 ml/min/1.73m2).
* Inability to provide informed consent (e.g. cognitive impairment).
* Unrelated condition (e.g. neoplasm) with life expectancy \<12 months prohibiting follow-up.
* Patients with contraindications to gadolinium (known or suspected hypersensitivity, glomerular filtration rate \< 30 ml/min/1.73m2) will undergo non-contrast MRI but will not be excluded from this study.
* Patients with known or suspected pregnancy based on Weill Cornell Radiology intake surveys (reviewed by a clinical RN (registered nurse), as well as research personnel) will be excluded from the protocol.

Where it's running

• New York Presbyterian-Brooklyn Methodist Hospital
  Brooklyn, New York, United States Recruiting
• New York Presbyterian Queens
  New York, New York, United States Recruiting
• Weill Cornell Medicine/New-York Presbyterian Hospital
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jiwon Kim, MD — Weill Medical College of Cornell University
• Study coordinator: Elizabeth Manowitz, BS
• Email: elm4036@med.cornell.edu
• Phone: 2127462627

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.