Understanding heart function in COVID-19 survivors using MRI
Cardiac Magnetic Resonance for Tissue Characterization-Based Risk Stratification of Cardiopulmonary Symptoms, Effort Tolerance, and Prognosis Among COVID-19 Survivors
This study is trying to see how heart scans can help understand heart function and long-term symptoms in people who have survived COVID-19.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 510 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 3 sites (Brooklyn, New York and 2 other locations) |
| Trial ID | NCT05164744 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the role of cardiac magnetic resonance imaging (CMR) and echocardiograms in assessing heart function and predicting long-term cardiopulmonary symptoms in survivors of COVID-19. By analyzing myocardial tissue characteristics, the research seeks to identify potential causes of persistent symptoms such as fatigue and dyspnea. The study will utilize data from a diverse registry of COVID-19 survivors in New York City, focusing on the relationship between cardiac abnormalities and clinical outcomes. The findings could lead to targeted therapies for affected individuals.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have been hospitalized or presented to the emergency room with confirmed COVID-19 infection.
Not a fit: Patients with contraindications to cardiac MRI or gadolinium, or those with unrelated life-limiting conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could help identify the underlying causes of lasting cardiopulmonary symptoms in COVID-19 survivors and inform the development of effective treatments.
How similar studies have performed: While some studies have indicated cardiac abnormalities in COVID-19 survivors, this research aims to provide a more comprehensive understanding and is considered a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Emergency room presentation and/or hospitalization with COVID-19 infection defined in accordance with established criteria as follows: SAR-CoV2 RT-PCR+ (severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction) and at least one of the following symptoms: dyspnea, cough, dysphagia, rhinorrhea, diarrhea, nausea/vomiting, myalgias, fever, syncope/presyncope. Exclusion criteria: * Contraindication to CMR (i.e. non-compatible pacemaker/defibrillator) or gadolinium (known hypersensitivity, eGFR (estimated globular filtration rate) \<30 ml/min/1.73m2). * Inability to provide informed consent (e.g. cognitive impairment). * Unrelated condition (e.g. neoplasm) with life expectancy \<12 months prohibiting follow-up. * Patients with contraindications to gadolinium (known or suspected hypersensitivity, glomerular filtration rate \< 30 ml/min/1.73m2) will undergo non-contrast MRI but will not be excluded from this study. * Patients with known or suspected pregnancy based on Weill Cornell Radiology intake surveys (reviewed by a clinical RN (registered nurse), as well as research personnel) will be excluded from the protocol.
Where this trial is running
Brooklyn, New York and 2 other locations
- New York Presbyterian-Brooklyn Methodist Hospital — Brooklyn, New York, United States (Recruiting)
- New York Presbyterian Queens — New York, New York, United States (Recruiting)
- Weill Cornell Medicine/New-York Presbyterian Hospital — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Jiwon Kim, MD — Weill Medical College of Cornell University
- Study coordinator: Elizabeth Manowitz, BS
- Email: elm4036@med.cornell.edu
- Phone: 2127462627
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.