Understanding heart function and blood flow changes during anesthesia
Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)
Memorial Sloan Kettering Cancer Center · NCT05954832
This study looks at how general anesthesia affects heart function and blood flow in adults having surgery, especially those who have low blood pressure after anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center (other) |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05954832 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how general anesthesia affects heart function and blood flow in adult patients undergoing surgery. Researchers will focus on patients who experience low blood pressure after receiving anesthesia, using echocardiography to monitor changes in heart performance and circulation. The study will include adults requiring intubation for anesthetic management and will assess their heart function before and after anesthesia administration.
Who should consider this trial
Good fit: Ideal candidates are adult patients aged 18 and older who require general anesthesia and intubation for surgery.
Not a fit: Patients with a history of coronary artery disease, cardiac disease, or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of heart function during anesthesia, enhancing patient safety and outcomes.
How similar studies have performed: While there have been studies on heart function during anesthesia, this specific focus on blood flow changes in patients with hypotension is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients ≥ 18 years of age requiring general anesthesia for surgery * Intubation required for anesthetic management / surgery * Anticipated prep time before incision of 20 minutes * Baseline MAP \>70mmHg Exclusion Criteria: * History of coronary artery disease * History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities) * History of peripheral artery occlusive disease * Beta-blocker use * Anti-hypertensive medication use * Patients with epidural, spinal, paravertebral, serratus blocks preoperatively * Patients requiring rapid sequence induction (where intubation occurs concurrently with induction) * Emergency surgery
Where this trial is running
New York, New York
- Memorial Sloan Kettering Cancer Center (All protocol activites) — New York, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Anahita Dabo-Trubelja, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Anahita Dabo-Trubelja, MD
- Email: daboa@mskcc.org
- Phone: 212-639-3279
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Anesthesia, Changes in Heart Function, Changes in Blood Flow, Echocardiography, 23-079