Understanding heart dysfunction in critically ill patients
Aetiology and Clinical Importance of Acute Cardiac Dysfunction in Critical Illness
This study looks at how heart problems affect critically ill patients with multiple organ failure to see how it impacts their recovery and long-term health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 592 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Västra Frölunda, Please Select) |
| Trial ID | NCT05860504 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the incidence and impact of cardiac dysfunction on short- and long-term outcomes in critically ill patients experiencing multi-organ failure. It will explore the pathogenesis of cardiac dysfunction and identify key molecules associated with this condition. The study will utilize echocardiography, cardiac magnetic resonance imaging, and coronary CT to gather data on patients admitted to the ICU with significant organ dysfunction. By analyzing these factors, the research seeks to enhance understanding of heart failure in critical illness.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who are admitted to the ICU within 24 hours and exhibit significant dysfunction in at least two organ systems.
Not a fit: Patients who do not undergo echocardiographic examination or retract consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management and treatment strategies for critically ill patients with cardiac dysfunction.
How similar studies have performed: While there is limited research on cardiac dysfunction in critical illness, existing studies suggest that left ventricular dysfunction is common and associated with higher mortality, indicating potential for impactful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged \> 18 years 2. Admitted to a participating ICU within 24 hours 3. Significant organ dysfunction involving at least two organ systems. This is defined as fulfilling both of the following: * At least 4 points on the SOFA scale (Sequential Organ Failure Assessment scale) * Having at least 1 point on the SOFA scale from at least two organ systems 4. Given informed consent from patient or permission to participate from next of kin Exclusion Criteria: 1. Echocardiographic examination not possible (e.g., pneumothorax, draping etc) or very low echocardiographic examination quality 2. Not being examined with echocardiography within 24 hours from inclusion 3. Retracted consent to participate
Where this trial is running
Västra Frölunda, Please Select
- Sahgrensak University Hospital — Västra Frölunda, Please Select, Sweden (Recruiting)
Study contacts
- Study coordinator: Jonatan Oras, MD, PhD
- Email: jonatan.oras@vgregion.se
- Phone: +46313421000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.