Understanding genetic causes of eye surface disorders
Official title: Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT02886611 · Data updated 2026-11-12
This study is trying to find out how certain genetic factors affect the eye problems of people with limbal stem cell deficiency.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | December 15, 2015 |
| Main results expected | December 2025 |
| Study ends | December 2026 |
| Registry record updated | December 3, 2025 |
| Trial ID | NCT02886611 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with genetic pathologies affecting the ocular surface.
✕Probably not a fit
Patients with conditions like agonal glaucoma or low vision primarily due to retinal issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the correlation between genetic factors and clinical outcomes in patients suffering from limbal stem cell deficiency due to genetic origins. By analyzing the genotype-phenotype relationship, the study aims to identify specific genetic abnormalities that are linked to severe clinical manifestations. The research is conducted at the Fondation Ophtalmologique Adolphe de Rothschild in Paris, focusing on patients with ocular surface genetic pathologies.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of genetic eye disorders, improving patient outcomes.
How similar studies have gone: While this study focuses on a specific genetic correlation, similar studies have shown promise in understanding genetic influences on other ocular conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * genetic pathology of ocular surface Exclusion Criteria: * Agonal glaucoma * Low vision mostly related to retinal pathology * Pregnant or breast feeding patient
Where it's running
-
Fondation Ophtalmologique Adolphe de Rothschild
Paris, France Recruiting
Study contacts
- Principal investigator: Anna GEMAHLING, MD — Hôpital Fondation Adolphe de Rothschild
- Study coordinator: Amélie YAVCHITZ, MD, PhD
- Email: ayavchitz@for.paris
- Phone: 0033148036454
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.