Understanding Fibromuscular Dysplasia and Related Arteriopathies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to establish a comprehensive library of biological samples from patients diagnosed with Fibromuscular Dysplasia (FMD), Spontaneous Coronary Artery Dissection (SCAD), and Cervical Artery Dissection (CvAD), alongside healthy control subjects. The study will conduct a cross-tissue systems genetics analysis to identify key regulatory gene networks and disease drivers associated with these conditions. By comparing the molecular and genomic profiles of these disorders, the research seeks to uncover the underlying biological mechanisms that contribute to their development.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of any age and freely willing to participate. For patients \< 18 years of age consent will be via parents.
* Fluency in either English or Spanish.
* Signed, informed consent
* For FMD, SCAD or CvAD subjects - a clinical diagnosis of FMD, SCAD or CvAD with fulfillment of standard diagnostic criteria.
* For healthy controls - no clinical features of FMD, SCAD or CvAD and absence of any major ongoing systemic disease including any condition requiring hospitalization, immune suppression, intravenous or injected medications or that result in functional impairment in the performance of activities of daily living. Healthy controls will be matched to enrolled FMD patients on the basis of gender and approximate age (within a 5 year window of another FMD subject).

Exclusion Criteria:

* Patients who have co-morbidities which reduces life expectancy to one year.
* Patients with any solid organ or hematological transplantation, or those in whom transplantation is considered.
* Active autoimmune disease.
* Illicit drug use.
* HIV positive.
* Prior malignancy.
* Any other form of vascular disease, including other arteriopathy coronary artery disease or peripheral vascular disease
* Family history of arteriopathy other than FMD, SCAD or CvAD (e.g. Ehlers-Danlos syndrome)

Where it's running

• Icahn School of Medicine at Mount Sinai
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jason Kovacic, MD, PhD — Icahn School of Medicine at Mount Sinai
• Study coordinator: Jason Kovacic, MD, PhD
• Email: jason.kovacic@mountsinai.org
• Phone: 212-241-7014

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for Spontaneous Coronary Artery Dissection

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.