Understanding febrile illness in rural South and Southeast Asia
Determining the Incidence, Causes and Outcomes of Rural Febrile Illness (RFI) in South and Southeast Asia, as Part of the South and Southeast Asian Community-based Trials Network (SEACTN). Work Package A (WP-A).
This study is trying to learn more about fevers in rural areas of South and Southeast Asia to help improve how we treat and manage these illnesses.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100000 (estimated) |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Locations | 7 sites (Dhaka and 6 other locations) |
| Trial ID | NCT04478578 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect data on the incidence, causes, and outcomes of febrile illness in rural communities across South and Southeast Asia, including countries like Cambodia, Laos, Myanmar, and Bangladesh. By engaging village health workers and local health centers, the study will recruit patients with documented fever and follow them for clinical outcomes. The research will utilize innovative diagnostic methods to enhance the understanding of febrile illnesses and inform future interventions. The findings are expected to contribute to the development of new tests and treatments for managing febrile patients.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals presenting with documented fever or a history of fever within the last 24 hours.
Not a fit: Patients currently enrolled in the study or those whose fever is due to trauma or recent immunizations may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management and treatment options for patients suffering from febrile illnesses in rural areas.
How similar studies have performed: Other studies have shown success in understanding febrile illnesses in similar settings, but this study aims to quantify the burden on an unprecedented scale.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Documented fever (≥ 37.5°C axillary), hypothermia (\< 35.5°C) and/or history of fever in the last 24 hours. * Willingness and ability to comply with study protocol for the study duration. * Written informed consent given to participate in the trial. Exclusion Criteria: * Currently enrolled in the study * Accident or trauma is the cause for presentation * Presentation ≤ 3 days after routine immunisations
Where this trial is running
Dhaka and 6 other locations
- Building Resources Across Communities (BRAC) — Dhaka, Bangladesh (Recruiting)
- Medical Action Myanmar (MAM) — Yangon, Burma (Not_yet_recruiting)
- Action for Health Development (AHEAD) — Battambang, Cambodia (Recruiting)
- Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU) — Vientiane, Vientiane Prefecture, Laos (Recruiting)
- Mahidol VivaResearch Unit, Faculty of Tropical Medicine, Mahidol University (MVRU) — Ratchathewi, Bangkok, Thailand (Recruiting)
- Shoklo Malaria Research Unit (SMRU) — Mae Sot, Changwat Tak, Thailand (Recruiting)
- Chiangrai Clinical Research Unit (CCRU) — Chiang Rai, Thailand (Recruiting)
Study contacts
- Principal investigator: Yoel Lubell, Prof — Mahidol Oxford Tropical Medicine Research Unit
- Study coordinator: Yoel Lubell, Prof.
- Email: yoel@tropmedres.ac
- Phone: +66-857201350
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.