Understanding factors affecting recovery after knee ligament surgery
JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction
This study looks at how different factors affect recovery after knee ligament surgery in young people with knee instability to see how well they do over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 850 (estimated) |
| Ages | 10 Years to 35 Years |
| Sex | All |
| Sponsor | Hospital for Special Surgery, New York Academic / other |
| Locations | 16 sites (Redwood City, California and 15 other locations) |
| Trial ID | NCT06883396 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the outcomes of medial patellofemoral ligament (MPFL) reconstruction in patients with recurrent patellar instability. It will collect data on various risk factors that may contribute to recurrent instability following the surgery, as well as functional outcomes reported by patients. Participants aged 10-35 will complete surveys about their knee function and activity levels one and two years post-surgery. The study is conducted by a group of experienced patellofemoral surgeons across the United States.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 10-35 with a history of recurrent patellar instability.
Not a fit: Patients with previous knee surgeries or fixed patellar dislocation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify patients at high risk for recurrent instability, leading to improved surgical strategies and outcomes.
How similar studies have performed: Other studies have explored similar surgical approaches, but this specific investigation into risk factors for MPFL reconstruction outcomes is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 10-35 years old * Recurrent patellar instability with at least one episode defined as either (1) a dislocated patella requiring reduction in the emergency department or (2) a convincing history for dislocation, associated with full giving way, and the following physical findings: (a) hemarthrosis or effusion, (b) tenderness along the medial retinaculum, and (c) apprehension when laterally directed force was applied to the patella or (3) MRI-documented dislocation with associated bone bruises Exclusion Criteria: * Previous ipsilateral knee surgery * Obligatory/fixed/habitual patella dislocation or subluxation * Unloadable inferior or lateral chondral damage on the patella that would require a tibial tubercle transfer for unloading purposes * Pathologic tibiofemoral instability
Where this trial is running
Redwood City, California and 15 other locations
- Stanford University — Redwood City, California, United States (Recruiting)
- University of Florida — Gainesville, Florida, United States (Recruiting)
- Midwest Orthopaedics at Rush — Chicago, Illinois, United States (Recruiting)
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
- Boston Children's Hospital — Boston, Massachusetts, United States (Recruiting)
- Mayo Clinic — Rochester, Minnesota, United States (Not_yet_recruiting)
- Mount Sinai — New York, New York, United States (Not_yet_recruiting)
- NYU Langone Health — New York, New York, United States (Recruiting)
- Hospital for Special Surgery — New York, New York, United States (Recruiting)
- Duke Health — Wake Forest, North Carolina, United States (Recruiting)
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (Recruiting)
- Cleveland Clinic — Cleveland, Ohio, United States (Not_yet_recruiting)
- Ohio State University Wexler Medical Center — Dublin, Ohio, United States (Recruiting)
- Oregon Health & Science University — Portland, Oregon, United States (Recruiting)
- Scottish Rite for Children — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Beth Shubin Stein, MD — Hospital for Special Surgery, New York
- Study coordinator: Simone Gruber
- Email: grubers@hss.edu
- Phone: 646-797-8947
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.