Understanding Eosinophils in Immune Conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the activation and function of eosinophils, a type of white blood cell, in patients with elevated eosinophil counts due to various immune system diseases. Participants will undergo thorough medical evaluations, including blood tests and potential collection of clinical samples, to explore the mechanisms behind eosinophilia and its impact on health. The study will also monitor the clinical and immunological responses to therapy, although it is not primarily focused on treatment. Family members of participants may also be included to help identify genetic factors related to eosinophilia.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

To be eligible to participate in this study, an individual must meet all of the following criteria:

1. Stated willingness to comply with all study procedures and availability for the duration of the study
2. Male or female, aged 1-100
3. Ability of subject (or Legally Authorized Representative (LAR)) to understand and sign a written informed consent document

   Eosinophilic Patients only:
4. Documented peripheral blood count \>1500/mm3, tissue eosinophilia (abnormal accumulation of eosinophils in the skin or other body tissues) or suspected eosinophilic end organ involvement
5. Primary (non-NIH) physician for routine medical care

   Relatives only:
6. Extended family member of an eosinophilic participant on this protocol

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Any condition(s) or diagnosis, physical and/or psychological, that the investigator feels precludes the patient from participation in the study.

   Relatives only:
2. Females must not be pregnant

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Amy D Klion, M.D. — National Institute of Allergy and Infectious Diseases (NIAID)
• Study coordinator: Lori A Penrod, R.N.
• Email: lori.penrod@nih.gov
• Phone: (240) 627-3647

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.