Understanding Eosinophils in Immune Conditions
Eosinophil Activation and Function in Parasitic Infections and Other Conditions With Increased Tissue or Peripheral Blood Eosinophilia in Humans
National Institutes of Health Clinical Center (CC) · NCT00001406
This study is trying to understand how certain white blood cells called eosinophils behave in people with high eosinophil counts due to immune system diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 1 Year to 100 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) (nih) |
| Locations | 1 site (Bethesda, Maryland) |
| Trial ID | NCT00001406 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the activation and function of eosinophils, a type of white blood cell, in patients with elevated eosinophil counts due to various immune system diseases. Participants will undergo thorough medical evaluations, including blood tests and potential collection of clinical samples, to explore the mechanisms behind eosinophilia and its impact on health. The study will also monitor the clinical and immunological responses to therapy, although it is not primarily focused on treatment. Family members of participants may also be included to help identify genetic factors related to eosinophilia.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 1 to 100 with eosinophil counts greater than 750/ml or abnormal eosinophil accumulation in tissues.
Not a fit: Patients without elevated eosinophil counts or those with conditions that preclude participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostics and novel treatment options for patients with eosinophilic disorders.
How similar studies have performed: While this study explores eosinophilia in depth, similar studies have shown promise in understanding immune responses, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Male or female, aged 1-100 3. Ability of subject (or Legally Authorized Representative (LAR)) to understand and sign a written informed consent document Eosinophilic Patients only: 4. Documented peripheral blood count \>1500/mm3, tissue eosinophilia (abnormal accumulation of eosinophils in the skin or other body tissues) or suspected eosinophilic end organ involvement 5. Primary (non-NIH) physician for routine medical care Relatives only: 6. Extended family member of an eosinophilic participant on this protocol EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Any condition(s) or diagnosis, physical and/or psychological, that the investigator feels precludes the patient from participation in the study. Relatives only: 2. Females must not be pregnant
Where this trial is running
Bethesda, Maryland
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (RECRUITING)
Study contacts
- Principal investigator: Amy D Klion, M.D. — National Institute of Allergy and Infectious Diseases (NIAID)
- Study coordinator: Lori A Penrod, R.N.
- Email: lpenrod@niaid.nih.gov
- Phone: (240) 627-3647
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Immune System Diseases, Eosinophilia, Helminthiasis, Hypersensitivity, Parasitic Disease, Eosinophils, Helminth Parasites, Hypereosinophilia