Understanding eosinophilic disorders and their mechanisms
Eosinophils and Inflammation, an Expanded Study
This study is trying to understand how certain immune cells behave in people with eosinophilic disorders, like food allergies and gastrointestinal issues, to see how these conditions affect their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Sex | All |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Trial ID | NCT00267501 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the mechanisms of eosinophil growth, survival, migration, and function in patients with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies. By collecting data and samples, the study seeks to characterize the pathophysiology and clinical manifestations of eosinophilic inflammation in humans. The research will involve patients diagnosed with these conditions as well as normal controls and family members. The findings could provide insights into the severity spectrum of these diseases.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies, as well as their family members.
Not a fit: Patients without a diagnosis of eosinophilic disorders or food allergies may not receive any benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of eosinophilic disorders, potentially improving diagnosis and treatment options for affected patients.
How similar studies have performed: While there have been studies on eosinophilic disorders, this specific approach to elucidate underlying mechanisms is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent obtained from the patient or parent/guardian. Assent will be obtained from all minors 11 years of age and older. * Carrying a diagnosis of eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergy OR family member, or normal control
Where this trial is running
Cincinnati, Ohio
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Marc E. Rothenberg, M.D., Ph.D. — Cincinnati Children's Hospital Medical Center
- Study coordinator: Bliss Magella
- Email: bliss.magella@cchmc.org
- Phone: 513-636-7832
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.