Understanding eosinophilic disorders and their mechanisms
Official title: Eosinophils and Inflammation, an Expanded Study
Run by Children's Hospital Medical Center, Cincinnati · NCT00267501 · Data updated 2026-11-12
This study is trying to understand how certain immune cells behave in people with eosinophilic disorders, like food allergies and gastrointestinal issues, to see how these conditions affect their health.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | May 2005 |
| Main results expected | January 2050 |
| Study ends | January 2050 |
| Registry record updated | September 17, 2025 |
| Trial ID | NCT00267501 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies, as well as their family members.
✕Probably not a fit
Patients without a diagnosis of eosinophilic disorders or food allergies may not receive any benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the mechanisms of eosinophil growth, survival, migration, and function in patients with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies. By collecting data and samples, the study seeks to characterize the pathophysiology and clinical manifestations of eosinophilic inflammation in humans. The research will involve patients diagnosed with these conditions as well as normal controls and family members. The findings could provide insights into the severity spectrum of these diseases.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of eosinophilic disorders, potentially improving diagnosis and treatment options for affected patients.
How similar studies have gone: While there have been studies on eosinophilic disorders, this specific approach to elucidate underlying mechanisms is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent obtained from the patient or parent/guardian. Assent will be obtained from all minors 11 years of age and older. * Carrying a diagnosis of eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergy OR family member, or normal control
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting
Study contacts
- Principal investigator: Marc E. Rothenberg, M.D., Ph.D. — Cincinnati Children's Hospital Medical Center
- Study coordinator: Bliss Magella
- Email: bliss.magella@cchmc.org
- Phone: 513-636-7832
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This study will test whether higher, weight-based doses of omalizumab are safe and help people with food allergies, including those with very high allergic antibody (IgE) levels, tolerate their allergens better.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.