Clinical trial Recruiting at 1 site Observational

Understanding eosinophilic disorders and their mechanisms

Official title: Eosinophils and Inflammation, an Expanded Study

Run by Children's Hospital Medical Center, Cincinnati · NCT00267501 · Data updated 2026-11-12

This study is trying to understand how certain immune cells behave in people with eosinophilic disorders, like food allergies and gastrointestinal issues, to see how these conditions affect their health.

Quick facts

Study typeObservational
SexAll
Enrollment5000 (estimated)
SponsorChildren's Hospital Medical Center, Cincinnati
Academic / other
Locations1 site (Cincinnati, Ohio)
StatusRecruiting
StartedMay 2005
Main results expectedJanuary 2050
Study endsJanuary 2050
Registry record updatedSeptember 17, 2025
Trial IDNCT00267501 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals diagnosed with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies, as well as their family members.

Probably not a fit

Patients without a diagnosis of eosinophilic disorders or food allergies may not receive any benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the mechanisms of eosinophil growth, survival, migration, and function in patients with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergies. By collecting data and samples, the study seeks to characterize the pathophysiology and clinical manifestations of eosinophilic inflammation in humans. The research will involve patients diagnosed with these conditions as well as normal controls and family members. The findings could provide insights into the severity spectrum of these diseases.

Why it matters

Potential benefit: If successful, this study could lead to a better understanding of eosinophilic disorders, potentially improving diagnosis and treatment options for affected patients.

How similar studies have gone: While there have been studies on eosinophilic disorders, this specific approach to elucidate underlying mechanisms is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Signed informed consent obtained from the patient or parent/guardian. Assent will be obtained from all minors 11 years of age and older.
* Carrying a diagnosis of eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergy OR family member, or normal control

Where it's running

  • Cincinnati Children's Hospital Medical Center
    Cincinnati, Ohio, United States
    Recruiting

Study contacts

  • Principal investigator: Marc E. Rothenberg, M.D., Ph.D. — Cincinnati Children's Hospital Medical Center
  • Study coordinator: Bliss Magella
  • Email: bliss.magella@cchmc.org
  • Phone: 513-636-7832

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.