Understanding different types of Acute Lung Injury and ARDS in patients
Official title: Acute Lung/ Acute Respiratory Distress Syndrome and Extra-pulmonary Organ Injury Clinical Sub-phenotyping Study
Run by China-Japan Friendship Hospital · NCT06123962 · Data updated 2026-11-12
This study is trying to understand the different types of Acute Lung Injury and ARDS in patients to help create better, personalized treatment plans.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | China-Japan Friendship Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | December 14, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | February 12, 2025 |
| Trial ID | NCT06123962 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults diagnosed with Acute Respiratory Distress Syndrome according to the latest global criteria.
✕Probably not a fit
Patients under 18 years old or those who decline to participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to create a structured clinical data and biosample platform for patients with Acute Lung Injury and Acute Respiratory Distress Syndrome (ARDS) in China. By analyzing the heterogeneity among these patients, the study seeks to develop clinical, physiological, and biological sub-phenotypes that can guide personalized treatment strategies. The research will involve collecting clinical data and biological samples from various provinces, utilizing mathematical and machine learning models to establish a classification system for the condition. The classification model will be validated using international databases and cohorts to ensure its reliability and applicability.
Why it matters
Potential benefit: If successful, this study could lead to improved individualized treatment strategies and better outcomes for patients with ARDS.
How similar studies have gone: Other studies have shown promise in sub-phenotyping ARDS, but this approach aims to create a comprehensive national database, making it a novel effort.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet the diagnostic criteria for Acute Respiratory Distress Syndrome (ARDS) according to the updated global definition in 2023. * The patient or their legal representative signs an informed consent form. Exclusion Criteria: * Individuals aged less than 18 years old. * Those who refuse to participate in the study.
Where it's running
-
Jingen Xia
Beijing, China Recruiting
Study contacts
- Study coordinator: Jingen Xia, M.D
- Email: 13466396561@163.com
- Phone: +8613466396561
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Assessing venous congestion in ARDS patients using ultrasound
This study is testing if using ultrasound can help find out how common venous congestion is in patients with acute respiratory distress syndrome who are on mechanical ventilation.
-
IC14 (anti-CD14) treatment for hospitalized patients with ARDS
This will test whether IC14, an antibody that blocks CD14, can improve oxygenation in adults hospitalized with ARDS who are on mechanical ventilation.
-
Prone positioning for infants with severe respiratory distress
This study is testing if putting infants with severe breathing problems on their stomachs helps them breathe better after receiving treatment.
-
Treating sepsis-related acute lung injury with gut microbiota transplantation
The team will test whether transplanting healthy gut bacteria can help adults with sepsis-related acute lung injury or ARDS recover better.
-
Understanding immune patterns and ECMO strategies to help adults with severe ARDS
This study tests how different immune and clinical patterns in adults with moderate-to-severe ARDS respond to ECMO and lung-protective care, aiming to improve outcomes.
-
Optimal corticosteroid dosing for ARDS: short vs. prolonged therapy
This trial tests different corticosteroid doses and treatment lengths to see which helps adults with ARDS who are on ventilators.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.