Understanding cognitive impairment caused by chemotherapy in breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the cognitive side effects, commonly referred to as 'chemobrain,' experienced by breast cancer patients undergoing chemotherapy. It focuses on understanding how chemotherapy may lead to inflammation in the brain, affecting memory and concentration. The study will utilize brain scans sensitive to excess iron to explore these changes, as direct measurement of the chemicals involved is not feasible. By gathering insights from patients during and after their treatment, the research seeks to fill critical gaps in knowledge regarding long-term cognitive effects of chemotherapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women and men \>18 years
* Diagnosed with HER2 negative breast cancer
* Receiving EC-Taxane or Taxane only based chemotherapy
* Able to communicate in English
* Willing and able to give informed consent for participation in the study.

Exclusion Criteria:

* Any patient whose physical condition will preclude them from lying still for the duration of the brain scan.
* pre-excisting mental condition/disability
* Contraindication to magnetic resonance scanning such as an implantable cardiac device.

Where it's running

• NHS Grampian
  Aberdeen, United Kingdom Recruiting

Study contacts

• Study coordinator: Teresa Morris
• Email: t.morris@abdn.ac.uk
• Phone: +44 + 1224438363

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.