Understanding cognitive decline in older adults with Alzheimer's disease
A Cohort Study of Cognitive Decline in Alzheimer Disease
This study looks at older adults with Alzheimer's disease to see how different factors like brain scans, blood tests, and physical activity might affect how quickly their thinking skills decline.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 65 Years to 92 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT03946930 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the risk factors associated with accelerated cognitive decline in older individuals diagnosed with Alzheimer's disease (AD). It will utilize an ongoing AD registry that includes detailed neurocognitive assessments, lifestyle information, and volumetric MRI brain scans. The study will explore the relationships between MRI brain volumes, serum biomarkers, physical activity, and cognitive decline, with the goal of identifying independent risk factors that contribute to the progression of AD.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults diagnosed with Alzheimer's disease who can communicate in Cantonese.
Not a fit: Patients who are unable to provide reliable information due to lack of a family caregiver or those who refuse blood sampling may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive decline in patients with Alzheimer's disease.
How similar studies have performed: While there have been studies exploring cognitive decline in Alzheimer's disease, this specific approach focusing on MRI volumes and biomarkers in a cohort setting is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sufficient Cantonese competency for cognitive test * Clinical diagnosis of AD * FAST test staging 3-5 Exclusion Criteria: * Subjects who refuse blood taking procedure * No reliable family caregiver informant (person contact at least once a month)
Where this trial is running
Hong Kong
- The Chinese University of Hong Kong — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Timothy Kwok, MD
- Email: tkwok@cuhk.edu.hk
- Phone: +852 35053145
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.