Understanding Circadian Rhythms in Human Fat Tissue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the circadian rhythms in subcutaneous adipose tissue among individuals with and without obesity, focusing on how these rhythms are affected by different feeding patterns. It will investigate the intrinsic circadian clock of adipocytes independent of nutrient delivery and assess the impact of central obesity on these rhythms. The study will involve 20 normal weight adults who will be randomized into two feeding groups: continuous feeding via a nasogastric tube or intermittent feeding with three meals a day. Participants will undergo various assessments, including body composition analysis and sleep quality monitoring, to gather comprehensive data on adipose tissue function and circadian rhythms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI 20-25 kg/m2 or 30-37 kg/m2
* For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
* sedentary
* females: non pregnant or breastfeeding
* ability to provide written informed consent and follow study instructions

Exclusion Criteria:

* History of mediations that impact adipocyte/lipid metabolism
* smoking
* insomnia
* sleep apnea
* sleep medication use
* employment in night or shift work
* extreme chronotypes
* Allergy to lidocaine

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Study coordinator: Kelli A Lytle, PhD
• Email: lytle.kelli@mayo.edu
• Phone: 507-255-1488

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.