Understanding Chronic Lymphocytic Leukemia
Run by Dana-Farber Cancer Institute · NCT04028531 · Data updated 2026-11-12
This study is collecting tissue samples and medical information from people with Chronic Lymphocytic Leukemia to see what causes the disease and find better treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2750 (estimated) |
| Sponsor | Dana-Farber Cancer Institute Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | September 29, 1999 |
| Main results expected | September 29, 2030 |
| Study ends | September 29, 2032 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT04028531 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study include new and existing patients diagnosed with Chronic Lymphocytic Leukemia or related low-grade lymphoproliferative disorders.
✕Probably not a fit
Patients who do not have Chronic Lymphocytic Leukemia or related conditions may not receive any benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect tissue samples and medical information from patients with Chronic Lymphocytic Leukemia (CLL) to investigate the underlying causes and biology of the disease. By analyzing these samples, researchers hope to gain insights that could lead to the development of more effective therapies for CLL. The study includes both new and existing patients treated at the Dana-Farber Cancer Institute and focuses on various low-grade lymphoproliferative disorders.
Why it matters
Potential benefit: If successful, this study could lead to improved therapies for patients suffering from Chronic Lymphocytic Leukemia.
How similar studies have gone: Other studies focusing on the biology of Chronic Lymphocytic Leukemia have shown promise, suggesting that this approach could yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * New and existing patients seen for treatment of monoclonal B-cell lymphocytosis * Any low grade lymphoproliferative disorder * Chronic Lymphocytic Leukemia in the Dana Farber Cancer Institute Hematologic Oncology Clinic or elsewhere Exclusion Criteria: \-
Where it's running
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Dana Farber Cancer Institute
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Jennifer Brown, MD,PhD — Dana-Farber Cancer Institute
- Study coordinator: Jennifer Brown, MD, PhD
- Email: Jennifer_brown@dfci.harvard.edu
- Phone: 617-582-8437
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Venetoclax plus Zanubrutinib for CLL/SLL in frontline or previously treated patients
This phase II trial tests if venetoclax plus zanubrutinib can safely and effectively treat adults with chronic lymphocytic leukemia or small lymphocytic lymphoma, including those who are newly diagnosed and those who have had prior therapy.
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Tafasitamab plus Acalabrutinib and Venetoclax for newly treated CLL/SLL
This phase II study tests a combination of tafasitamab, acalabrutinib, and venetoclax in adults who are newly diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma to see if it is safe and effective.
-
Nemtabrutinib and venetoclax in untreated CLL/SLL
This phase 2 study tests whether combining nemtabrutinib with venetoclax can help people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
-
NX-5948 plus other medicines for B-cell cancers
This trial tests NX-5948 in combination with venetoclax, with or without anti-CD20 antibodies, for adults with CLL/SLL or B-cell lymphoma that has returned or worsened or is newly diagnosed but needing treatment.
-
NX-5948 vs Pirtobrutinib in R/R CLL/SLL
This study tests NX-5948 against pirtobrutinib in people with relapsed or refractory CLL/SLL who have previously tried a covalent BTK inhibitor.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.