Understanding chronic ankle instability after an ankle sprain
Determining Key Clinical Predictors for Chronic Ankle Instability and Return to Sports With Cost of Illness Analysis: a Prospective Cohort Study
This study is trying to find out what factors can help predict if people aged 18-55 will develop ongoing ankle problems after a sprain and how soon they can get back to sports.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 265 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Universiteit Antwerpen Academic / other |
| Locations | 1 site (Edegem, Antwerpen) |
| Trial ID | NCT05637008 on ClinicalTrials.gov |
What this trial studies
This observational prospective cohort study aims to identify key clinical predictors for chronic ankle instability and the ability to return to sports in individuals who have experienced an acute ankle sprain. Participants will be evaluated at four different time points: 7-14 days, 6 weeks, 12 weeks, and 12 months following their injury. The study will utilize clinically applicable outcome measures and patient-reported outcomes to assess recovery and the development of chronic instability. Recruitment will occur through various healthcare settings and social media, focusing on physically active individuals aged 18-55.
Who should consider this trial
Good fit: Ideal candidates are physically active individuals aged 18-55 who have suffered an acute ankle sprain within the last 7 days.
Not a fit: Patients with recurrent ankle sprains, chronic ankle instability, or other significant lower limb injuries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into preventing chronic ankle instability and improving recovery strategies for athletes.
How similar studies have performed: Other studies have explored similar predictors for ankle instability, but this specific approach focusing on acute sprains and recovery in athletes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-55 years old * Acute ankle sprain: \<7 days * Athletes (recreational or professional) * Previous ankle sprain \>12 months Exclusion Criteria: * Recurrent ankle sprain * Ankle fracture * Chronic ankle instability * High ankle sprain (syndesmosis) * A history of ankle or foot operations * Other lower limb injuries and/or complaints * Severe ocular impairments * Any neurological, cardiac, vascular or metabolic disease
Where this trial is running
Edegem, Antwerpen
- Universitair Ziekenhuis Antwerpen — Edegem, Antwerpen, Belgium (Recruiting)
Study contacts
- Principal investigator: Dirk Vissers, Prof. — Universiteit Antwerpen
- Study coordinator: Jente Wagemans, MSc
- Email: jente.wagemans@uantwerpen.be
- Phone: 0032473293079
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.