Understanding causes and outcomes of febrile illness in rural South and Southeast Asia
Determining the Causes and Outcomes of Febrile Illness in Health Care Facilities in Rural South and Southeast Asia, as Part of the South and Southeast Asian Community-based Trials Network (SEACTN). Work Package B (WP-B).
This study is trying to find out what causes fevers and how they affect people living in rural areas of Laos, Myanmar, Thailand, and Bangladesh to help improve health care in those communities.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 7200 (estimated) |
| Ages | 29 Days and up |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Locations | 4 sites (Dhaka and 3 other locations) |
| Trial ID | NCT04629053 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify the causes and clinical outcomes of acute febrile illness in patients over 28 days old residing in rural areas of Laos, Myanmar, Thailand, and Bangladesh. By collecting data from local health facilities and village health workers, the study seeks to quantify the burden of febrile illness and understand its impact on these communities. The findings will help inform future interventions to address health issues in these low- and middle-income regions, where febrile illnesses are prevalent but under-researched.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals over 28 days old presenting with acute febrile illness lasting 14 days or less.
Not a fit: Patients whose febrile illness is due to trauma or who have been afebrile for less than 72 hours prior to assessment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of febrile illnesses, ultimately reducing morbidity and mortality in affected populations.
How similar studies have performed: While there is limited data on similar studies in these specific regions, the approach of investigating febrile illness in low-resource settings has shown promise in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study; 2. Aged \> 28 days (day of birth = Day 1); 3. Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR \< 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation; 4. Onset of illness ≤ 14 days Exclusion Criteria: 1. Accident or trauma is the cause for the patient's presentation; 2. Presentation ≤ 3 days after routine immunisations 3. Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period. 4. The treating healthcare worker's decision is to send the patient home following initial assessment.
Where this trial is running
Dhaka and 3 other locations
- Building Resources Across Communities (BRAC) — Dhaka, Bangladesh (Not_yet_recruiting)
- Laos-Oxford-Mahosot Wellcome Trust Research Unit — Vientiane, Laos (Recruiting)
- Shoklo Malaria Research Unit — Mae Sot, Changwat Tak, Thailand (Recruiting)
- Chiangrai Clinical Research Unit (CCRU) — Chiang Rai, Thailand (Recruiting)
Study contacts
- Principal investigator: Yoel Lubell, Prof. — Mahidol Oxford Tropical Medicine Research Unit
- Study coordinator: Yoel Lubell, Prof.
- Email: yoel@tropmedres.ac
- Phone: +66-857201350
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.