Understanding brain stimulation effects in military veterans with depression
Investigation of Sensory Synchronized Human Brain Imaging and Neuromodulation
This study is testing different types of brain stimulation to see how they can help military veterans with depression feel better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (Palo Alto, California) |
| Trial ID | NCT06548113 on ClinicalTrials.gov |
What this trial studies
This research focuses on exploring how different types of transcranial magnetic stimulation (TMS) affect brain activity in adult military veterans suffering from major depressive disorder. By analyzing the changes in brain function resulting from various TMS techniques, the study aims to develop personalized brain stimulation therapies tailored to individual needs. The study involves adult participants who are military veterans and will assess their responses to TMS interventions. The ultimate goal is to enhance treatment options for depression in this population.
Who should consider this trial
Good fit: Ideal candidates for this study are English-speaking military veterans aged 18 and older who are experiencing major depressive disorder.
Not a fit: Patients with contraindications for MRIs, a history of seizures, or other significant neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized treatments for major depressive disorder in military veterans.
How similar studies have performed: Other studies have shown promise in using TMS for treating depression, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women, ages 18 years and up * English speaking * Military Veterans Exclusion Criteria: * Those with a contraindication for MRIs (e.g. implanted metal) * History of head trauma with loss of consciousness * History of seizures or on medications that substantially reduce seizure threshold * Neurological or uncontrolled medical disease * Active substance abuse * Currently pregnant or breastfeeding
Where this trial is running
Palo Alto, California
- VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States (Recruiting)
Study contacts
- Principal investigator: Jessica M Ross, PhD — VA Palo Alto Health Care System, Palo Alto, CA
- Study coordinator: Jessica M Ross, PhD
- Email: jessica.ross1@va.gov
- Phone: (530) 902-2450
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.