Understanding brain lesions in multiple sclerosis and related disorders
Longitudinal Investigation of Cortical Demyelination and Meningeal Inflammation in Multiple Sclerosis and Related Disorders
This study looks at how brain lesions develop in people with multiple sclerosis and similar conditions over time to better understand their effects and progression.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Icahn School of Medicine at Mount Sinai Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05982925 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the natural history and immunologic mechanisms of central nervous system lesions, particularly in the cerebral cortex, in patients with multiple sclerosis and other demyelinating autoimmune diseases. Participants, including healthy controls, will undergo a series of evaluations including MRI scans, blood tests, and cerebrospinal fluid analysis at baseline and follow-ups over six years. The study will also monitor new lesion formation and compare different MRI techniques. The goal is to gain insights into the clinical implications of these lesions and their progression over time.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with multiple sclerosis, neuromyelitis optica, or other demyelinating autoimmune diseases.
Not a fit: Patients who are pregnant or have contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of multiple sclerosis and related disorders, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: While this study employs established methodologies, the specific focus on longitudinal cortical demyelination in this context may provide novel insights, as similar studies have shown varying degrees of success in understanding CNS lesions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old * able to provide consent in English * able to undergo MRI Exclusion Criteria: * contraindication to MRI * pregnancy
Where this trial is running
New York, New York
- Mount Sinai Hospital — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Erin S Beck, MD, PhD — Icahn School of Medicine at Mount Sinai
- Study coordinator: Erin S Beck, MD, PhD
- Email: erin.beck@mssm.edu
- Phone: 212-241-2474
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.