Understanding brain injury after cardiac arrest
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest
NA · University of British Columbia · NCT05390060
This study is trying to see if different types of brain injuries after cardiac arrest affect how well oxygen gets to the brain, to help improve care for patients.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | University of British Columbia (other) |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT05390060 on ClinicalTrials.gov |
What this trial studies
This study aims to differentiate between two types of hypoxic ischemic brain injury (HIBI) in patients who have experienced cardiac arrest. It will evaluate patients' oxygen transport dynamics to determine if they exhibit normal or impaired oxygen delivery to the brain. The research will involve neuromonitoring and various assessments to explore the underlying mechanisms of oxygen transport limitations and their impact on clinical outcomes. By identifying these differences, the study seeks to improve management strategies for post-cardiac arrest patients.
Who should consider this trial
Good fit: Ideal candidates are adults over 19 years old who have experienced cardiac arrest and have a Glasgow Coma Scale score of 8 or less.
Not a fit: Patients with coagulopathy, severe traumatic brain injury, or those currently on anticoagulant medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better-targeted treatments for patients suffering from brain injuries after cardiac arrest.
How similar studies have performed: While there have been studies on hypoxic ischemic brain injury, this approach of differentiating between oxygen transport dynamics is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1) Greater than 19 years old post cardiac arrest with a Glasgow Coma Scale of 8 or less * 2) Invasive monitoring implemented within 72 hours of cardiac arrest * 3) Duration of cardiac arrest greater than 10 minutes. Exclusion Criteria: * 1) Coagulopathy (INR \> 1.5, PTT \> 40, Platelets \< 100x106 per microliter) * 2) Current or anticipated use of anticoagulant or antiplatelet medication * 3) Target temperature under 35oC; 4) history of severe TBI, intracranial hemorrhage or stroke.
Where this trial is running
Vancouver, British Columbia
- Vancouver General Hospital — Vancouver, British Columbia, Canada (RECRUITING)
Study contacts
- Study coordinator: Rebecca Grey
- Email: Rebecca.Grey@vch.ca
- Phone: 604-875-4111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypoxia-Ischemia, Brain