Understanding brain changes related to chronic pain in cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify and characterize the disruption patterns in sensorimotor networks associated with chronic pain and sensory deficits in individuals with cerebral palsy (CP). By utilizing existing medical records, subjective reports, and MRI data, the researchers will non-invasively explore the correlation between brain injuries and pain mechanisms. The study seeks to improve the understanding of how anatomical brain changes relate to pain and sensory loss, potentially leading to better precision in diagnosing and managing pain subtypes in CP patients.

Why it matters

Who can join: the full rules

Participants with CP (Survey-only):

Inclusion Criteria:

* Individual 8+ years of age
* Diagnosis of cerebral palsy

Exclusion Criteria:

-None

Neurotypical participants: (Survey-only):

Inclusion Criteria:

* Individual 8+ years of age
* Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents

Exclusion Criteria:

-Clinically-significant neurologic or developmental diagnosis

Participants with CP (Survey and MRI):

Inclusion Criteria:

* Individual 8+ years of age
* Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
* Diagnosis of cerebral palsy
* Clinical imaging demonstrating isolated periventricular white matter injury
* Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury
* Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI

Exclusion Criteria:

-None

Neurotypical participants (Survey and MRI):

Inclusion Criteria:

* Individual 8+ years of age
* Adult subject able to indicate understanding and affirmative consent
* Able to lie still in scanner for 1.5 hours and be able to have MRI

Exclusion Criteria:

-Clinically-significant neurologic or developmental diagnosis

Where it's running

• F.M. Kirby Center
  Baltimore, Maryland, United States Recruiting
• Mt. Washington Pediatric Hospital
  Baltimore, Maryland, United States Recruiting
• Johns Hopkins Hospital
  Baltimore, Maryland, United States Recruiting
• Kennedy Krieger Institute
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Eric Chin, MD — Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
• Study coordinator: Paul Salib, MS
• Email: CPpainStudy@kennedykrieger.org
• Phone: (443) 923-9272

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.