Understanding brain changes in children with spastic diplegia after surgery
Official title: Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
Run by The University of Texas Health Science Center, Houston · NCT02535936 · Data updated 2026-11-12
This study is trying to see how surgery affects brain connections in children with spastic diplegia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 3 Years to 18 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | August 2015 |
| Main results expected | January 1, 2030 |
| Study ends | January 1, 2031 |
| Registry record updated | December 11, 2024 |
| Trial ID | NCT02535936 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children diagnosed with spastic diplegia who have undergone Selective Dorsal Rhizotomy surgery.
✕Probably not a fit
Patients who have not undergone Selective Dorsal Rhizotomy surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate the changes in brain connectivity in children diagnosed with spastic diplegia following Selective Dorsal Rhizotomy. Using advanced imaging techniques such as diffusion tractography imaging (DTI) and resting state functional connectivity MRI (rsfcMRI), researchers will analyze the structural and functional alterations in the corticopyramidal tract. The study will compare these changes to better understand the impact of the surgical intervention on brain function and connectivity in affected children.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of brain recovery processes in children with spastic diplegia, potentially enhancing rehabilitation strategies.
How similar studies have gone: Other studies have shown promising results in understanding brain plasticity and recovery in similar patient populations, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery Exclusion Criteria: * No Selective Dorsal Rhizotomy surgery
Where it's running
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UTHealth & Children's Memorial Hermann Hospital
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Manish N Shah, MD — UTHealth Medical School
- Study coordinator: Manish N Shah, MD
- Email: Manish.N.Shah@uth.tmc.edu
- Phone: 713 500-7410
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.