Understanding brain activity related to movement in healthy adults
Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
This study is trying to see how brain activity related to movement works in healthy adults while they perform reaching and grasping tasks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT04727944 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between motor-related beta activity in the brain and naturalistic movements in healthy adults. Using neuroimaging techniques such as magnetoencephalography (MEG) and electroencephalography (EEG), participants will perform reach and grasp tasks to assess how beta burst activity correlates with their movements. The research aims to clarify the behavioral significance of beta activity, which is crucial for developing treatments for movement disorders like Parkinson's disease. By analyzing brain activity during these tasks, the study seeks to enhance our understanding of motor control mechanisms.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-40 who are right-handed and fluent in French.
Not a fit: Patients with movement disorders or psychiatric conditions such as Parkinson's disease or Alzheimer's disease will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that lead to improved treatments for movement disorders.
How similar studies have performed: While the specific approach of analyzing beta burst activity in naturalistic movements may be novel, similar studies have shown promise in understanding motor control and movement disorders.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For all experiments : * Healthy male or female * Aged 18-40 years * Registered with the French healthcare system * Motivated to participate in the study * Normal or corrected vision * Right-handed * Adequate knowledge of French to be able to follow directions * Subjects must have the minimal motor ability necessary to participate in the experiment * Subjects must be able to listen and understand the study instructions * Subjects must be able to give written informed consent before participation * Normal hearing Exclusion Criteria: For all experiments : Subjects with characteristics incompatible with MEG/EEG and MRI : * Claustrophobia * Psychiatric pathology characterized including Alzheimer's disease, Parkinson's disease, multiple sclerosis (MS), or severe traumatic brain injury * Neuropsychological disorders or cognitive impairment including schizophrenia, bipolar disorder, seizures, epilepsy, sleep disorders * Regular use of neurodevelopment medicines (antidepressants, neuroleptics) * Subject has a history of skin disease or skin allergies (multiple or severe) * Subject working with metals in their professional lives * The subject had an MRI 2 weeks prior to experiment 1 * Implanted material (any dental apparatus containing metal including or root canals or any metallic object, pacemaker, cochlear implanted in the body) * Pregnant women or lactating women (based on self-report) * subjects who are not able to tolerate sitting for 1 hour (the estimated length of the experiment) * Alcohol dependence * Subjects who, in the opinion of the investigator are not able or willing to comply with the protocol For experiment 1: - A head size incompatible with the use of a personalized 3D head-cast or a magnetoencephalography
Where this trial is running
Bron
- Institut des Sciences Cognitives, Marc Jeannerod, UMR 5229 CNRS — Bron, France (Recruiting)
Study contacts
- Principal investigator: James BONAIUTO — Institut des Sciences Cognitives, Marc Jeannerod, UMR 5229 CNRS
- Study coordinator: James BONAIUTO, MD
- Email: james.bonaiuto@isc.cnrs.fr
- Phone: 06 49 34 87 61
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.