Understanding blood flow regulation in health and disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the mechanisms that regulate blood flow to muscle tissues, particularly focusing on the role of the renin-angiotensin system and nitric oxide in vascular function. It aims to understand how aging and various diseases, such as COPD and heart failure, affect vascular tone and perfusion during exercise. The study involves maximum exercise tests and various interventions to assess their impact on vascular health and function. By comparing healthy young and older volunteers with patients suffering from chronic conditions, the research seeks to uncover the underlying factors contributing to vascular dysfunction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy Young Volunteers: 18-30 years of age with no diseases or conditions that would affect their participation in the study
* Healthy Older Controls: volunteers 65 years of age or older with no diseases or conditions that would affect their participation in the study
* Coronary Angiography subjects: patients undergoing routine coronary angiography
* Chronic Obstructive Pulmonary Disease subjects: patients diagnosed with mild to moderate COPD
* Pulmonary Arterial Hypertension subjects: patients with idiopathic or heritable Group 1 pulmonary arterial hypertension
* Heart Failure subjects: patients with Class I, II or III New York Heart Association symptoms of Heart Failure
* Hypertension subjects: patients diagnosed with chronic high blood pressure

Exclusion Criteria:

* Severe COPD (use of supplemental oxygen, or have a one-second forced expiratory volume of less than 30% predicted)
* History of myocardial infarction
* History of percutaneous coronary revascularization
* History of coronary artery bypass grafting
* Unstable angina pectoris
* History of variant angina
* Ejection fraction \< 50%
* Significant renal disease (Glomerular Filtration Rate \< 50 mL/min/1.73m2)
* Subjects whose medical care or safety may be at risk from undergoing a Magnetic Resonance Imaging examination (e.g. pacemaker, metal implants, certain types of heart valves)
* Subject is pregnant
* Subject has physical ailments (other than COPD, PAH, HF, or hypertension) that would prevent them from study participation in the judgment of the investigator

Where it's running

• University of Utah
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: David W Wray, Ph.D. — University of Utah
• Study coordinator: Jarred Iacovelli
• Email: jarred.iacovelli@utah.edu
• Phone: 801-581-7606

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.