Understanding blood flow in fat tissue of aging adults
Adipose Tissue Blood Flow in Aging Humans
This study is testing how blood flow in fat tissue changes between younger and older healthy adults to better understand the effects of aging.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06096532 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to investigate the differences in adipose tissue blood flow (ATBF) between younger and older healthy adults. Participants will undergo a series of assessments, including blood flow measurements using the xenon washout technique, abdominal adipose tissue biopsies, and a glucose tolerance test. The study seeks to identify molecular and systemic changes associated with ATBF in these age groups. By comparing the responses of younger and older adults, the research hopes to shed light on the physiological changes that occur with aging.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18-35 or 65-80 with a BMI between 20-25 kg/m².
Not a fit: Patients with diagnosed cardiometabolic diseases or those taking medications that affect adipose tissue metabolism will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of age-related changes in fat metabolism, potentially leading to better health strategies for older adults.
How similar studies have performed: While this specific approach is novel, similar studies have explored adipose tissue dynamics in aging, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria * Within the ages of 18-35 years or 65-80 years at time of study visit * BMI between 20-25.0 kg/m2. Exclusion criteria: * Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure) * Taking prescription anticoagulants * Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil) * Pregnant or nursing * Inability to provide written informed consent * Smokers
Where this trial is running
Rochester, Minnesota
- Mayo Clinic Minnesota — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Kelli Lytle, PhD — Mayo Clinic
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.