Understanding blood changes after exercise in people with restless legs syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate how exercise affects blood molecules in individuals diagnosed with restless legs syndrome (RLS). Participants will be randomly assigned to either an exercise group or a no-exercise group for 12 weeks. Blood samples will be collected before and after an exercise test to analyze changes in protein levels. The study seeks to determine the specific effects of long-term exercise compared to no exercise on blood proteins associated with RLS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age 18 years or older;
* diagnosis of RLS;
* presence of moderate-to-severe RLS (IRLS score\>15);
* currently untreated RLS;
* being non-active defined as not engaging in regular activity (30 minutes accumulated per day) on more than 2 days of the week during the previous six months;
* ability to walk without assistance (does not use a cane/walker/wheelchair for mobility;
* willing to complete outcome measures and complete the exercise program

Exclusion Criteria:

* present with a condition that can mimic RLS or cause secondary RLS (e.g., iron deficiency anemia, radiculopathy, peripheral edema, peripheral neuropathy, diabetes);
* are at moderate or high risk for undertaking strenuous or maximal exercise

Where it's running

• Stanford University
  Stanford, California, United States Recruiting

Study contacts

• Principal investigator: Emmanuel Mignot, MD, PhD — Stanford University
• Study coordinator: Katie Cederberg, PhD
• Email: kcederb@stanford.edu
• Phone: (650) 725-6517

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.