Understanding biomarkers in patients with spontaneous subarachnoid hemorrhage
Hemodynamic Instability of Patient With Spontaneous Subarachnoid Hemorrhage and Systemic Response to Endogenous Stress. Urinary and Serum Factors and Clinical Developments. Pilot Study Toward the Predictivity of Clinical Failure and Variation on Outcome in the Neurosurgical Patient (HISAHES)
This study is trying to see if certain blood and urine markers can help predict how well people with spontaneous subarachnoid hemorrhage will do after their condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Trial ID | NCT06218654 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of various biomarkers in predicting the clinical outcomes of patients with spontaneous subarachnoid hemorrhage (sSAH). Participants will provide regular blood and urinary samples to measure levels of specific biomarkers, including cardiac troponin, natriuretic peptides, and others. The study seeks to identify which biomarkers can serve as prognostic indicators and establish threshold levels that may predict patient outcomes. By analyzing these biomarkers, the study hopes to enhance understanding of the hemodynamic instability associated with sSAH.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients diagnosed with spontaneous subarachnoid hemorrhage confirmed through neuroimaging.
Not a fit: Patients under 18 years old or those with post-traumatic subarachnoid hemorrhage will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools for predicting outcomes in patients with spontaneous subarachnoid hemorrhage.
How similar studies have performed: While the approach of using biomarkers in sSAH is being explored, this specific study's focus on a comprehensive panel of biomarkers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with spontaneous subarachnoid hemorrhage, including those with perimesencephalic subarachnoid hemorrhage and aneurysmal subarachnoid hemorrhage. * Adult patients. * Confirmed presence of spontaneous subarachnoid hemorrhage through neuroimaging. * Obtained informed consent for specific study biomarkers Exclusion Criteria: * Age \<18 years. * Post-traumatic subarachnoid hemorrhage.
Where this trial is running
Roma
- Fondazione Policlinico Universitario A. Gemelli IRCCS — Roma, Italy (Recruiting)
Study contacts
- Principal investigator: Giuseppe Maria Della Pepa — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Study coordinator: Giuseppe Maria Della Pepa
- Email: giuseppemaria.dellapepa@policlinicogemelli.it
- Phone: +390630155701
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.