Understanding biomarkers and outcomes in Charcot-Marie-Tooth disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the progression of Charcot-Marie-Tooth disease type 1A (CMT1A) by identifying risk factors that influence the disease course. Over five years, researchers will analyze biomarkers from blood and skin samples of CMT patients, alongside a control group of healthy volunteers, to validate sensitive outcome measures. The study seeks to document symptom variability and disease dynamics, which could support the development of novel therapies for this hereditary neuropathy. By correlating molecular analyses with clinical data, the research hopes to establish practical biomarkers for monitoring disease severity and progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical CMT Diagnosis / Anamnestically Healthy Control Group
* Genetic confirmation of CMT in adult patients
* Ability to achieve the outcome measure at baseline
* Age between 18 and 65 years
* Capacity of all study participants to consent and signed informed consent, including patient or participant information and consent form

Exclusion Criteria:

* Pregnancy or breastfeeding period
* Other relevant neurological or psychiatric disorders, acute or in the past history
* Presence of a serious previous internal disease

Where it's running

• University Medical Centre
  Göttingen, Lower Saxony, Germany Recruiting

Study contacts

• Study coordinator: Michael W Sereda, Prof. MD
• Email: sereda@mpinat.mpg.de
• Phone: +49 551 3964162

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Multi-omic search for early biomarkers in CMT1A

  This project will test whether blood-based molecular signatures and qMRI measures in children and young adults with CMT1A can predict how the disease will progress.

  Recruiting University Medical Center Goettingen · Göttingen · NCT07476365

• Autonomic problems in Charcot–Marie–Tooth disease

  This study will test how common and how severe autonomic (automatic nervous system) symptoms are in adults aged 18–65 with genetically confirmed Charcot–Marie–Tooth disease compared with healthy volunteers.

  Recruiting University Medical Center Goettingen · Göttingen, Lower Saxony · NCT07570446

• Tremor in Charcot–Marie–Tooth disease

  Try to characterize tremor in adults with Charcot–Marie–Tooth (CMT) disease using surface electromyography, accelerometers, a clinical exam and questionnaires to see how tremor affects daily life.

  Recruiting University Medical Center Goettingen · Göttingen, Lower Saxony · NCT07570459

• Nerve function and structure in CMT, anti‑MAG neuropathy, and CIDP

  This project will test nerve‑conduction, axonal‑excitability, skin biopsy, and ultrasound measures in adults with CMT, CIDP, or anti‑MAG neuropathy to see if they better describe nerve function and structure.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan · NCT07461896

• Ankle-foot braces versus surgery to improve walking and balance in CMT

  This will test whether ankle-foot braces or surgical correction better improve walking, balance, and mobility for people aged 12 to 75 with genetically confirmed Charcot–Marie–Tooth disease.

  Recruiting University of Iowa · North Liberty, Iowa · NCT07188415

• 8-week lower-limb resistance program for young people with Charcot–Marie–Tooth disease

  This program will test whether 8 weeks of supervised lower-limb resistance exercises help improve muscle quality, functional ability, and quality of life in 15–29 year olds with and without Charcot–Marie–Tooth disease.

  Recruiting Universidad de La Frontera · Temuco, La Araucanía and 1 other locations · NCT07152197

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.