Understanding asthma and wheeze in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the underlying mechanisms that determine different asthma and wheeze trajectories in children and their transition into adulthood. By establishing a clinical cohort of children with new-onset wheeze or asthma, the study will utilize standardized instruments and quality control measures across multiple sites to gather data on genetic, environmental, and molecular factors. The goal is to develop personalized treatment approaches that target distinct mechanisms of asthma, potentially leading to secondary prevention early in the disease process.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* informed consent by parents (and by children if age \> 8 years)
* age 6 months to 18 years
* term delivery (≥ 37 weeks)
* active/passive understanding of German
* age 6 months - \< 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion)
* age at least 6 years: doctor diagnosed asthma (according to current guidelines)

Exclusion Criteria:

* known inborn or perinatal pulmonary disease
* airway malformation
* oxygen therapy after birth with a duration of more than 24 hours
* ventilator support or mechanical ventilation after birth
* diagnoses of cystic fibrosis; primary ciliary dyskinesia
* heart failure diagnosed after birth affecting pulmonary circulation
* major respiratory diseases such as e.g. interstitial lung disease
* any current non-atopic comorbidity
* fever of at least 38.5°C during the last two weeks prior to the planned first visit

Where it's running

• University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology
  Cologne, Germany Recruiting
• Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease
  Hanover, Germany Recruiting
• Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North
  Lübeck, Germany Recruiting
• Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center
  Marburg, Germany Recruiting
• Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich
  Munich, Germany Recruiting

Study contacts

• Principal investigator: Bianca Schaub, MD — Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich
• Study coordinator: Esther Zeitlmann, Diplom
• Email: esther.zeitlmann@med.uni-muenchen.de
• Phone: +49894400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.