Understanding Anomalous Aortic Origin of Coronary Artery
Anomalous Aortic Origin of Coronary Artery: From Pathophysiology to Risk Stratification Through a Patient Specific Computational Simulation Model
IRCCS Policlinico S. Donato · NCT05692063
This study looks at patients with Anomalous Aortic Origin of Coronary Artery to see what factors might lead to heart problems and to track any rare issues over time after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Sex | All |
| Sponsor | IRCCS Policlinico S. Donato (other) |
| Locations | 1 site (San Donato Milanese, MI) |
| Trial ID | NCT05692063 on ClinicalTrials.gov |
What this trial studies
This project aims to analyze clinical data and conduct computational simulations related to Anomalous Aortic Origin of the Coronary Artery (AAOCA). It includes a retrospective review of patients treated surgically and followed medically to identify risk factors for ischemia or sudden cardiac death. Additionally, there will be a prospective follow-up of enrolled patients to monitor for rare adverse events over time. The study will also involve retrieving morphological measurements from imaging studies and constructing a parametric model of the aortic root.
Who should consider this trial
Good fit: Ideal candidates include adults and children diagnosed with AAOCA without other congenital heart diseases.
Not a fit: Patients with other major congenital heart diseases or those with anomalous coronary artery origins from the pulmonary artery will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of AAOCA and improve patient outcomes by identifying risk factors and potential complications.
How similar studies have performed: While there may be studies on coronary artery anomalies, this specific approach combining clinical data analysis with computational modeling is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients (adults and pediatrics) who have been diagnosed with an anomalous aortic origin of any of the coronary arteries (AAOCA) without any other congenital heart disease and diagnosed/referred or followed at the IRCCS Policlinico San Donato. Exclusion Criteria: * Patients with other major congenital heart disease with associated coronary artery origin anomalies will be excluded. Patients with anomalous origin of the coronary artery from the pulmonary artery (ALCAPA or ARCAPA) will be excluded. Patients women who are pregnant.
Where this trial is running
San Donato Milanese, MI
- Irccs Policlinico San Donato — San Donato Milanese, MI, Italy (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Anomalous Aortic Origin of the Coronary Artery