Understanding Anomalous Aortic Origin of Coronary Artery
Official title: Anomalous Aortic Origin of Coronary Artery: From Pathophysiology to Risk Stratification Through a Patient Specific Computational Simulation Model
Run by IRCCS Policlinico S. Donato · NCT05692063 · Data updated 2026-11-12
This study looks at patients with Anomalous Aortic Origin of Coronary Artery to see what factors might lead to heart problems and to track any rare issues over time after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (San Donato Milanese, MI) |
| Status | Recruiting |
| Started | June 27, 2019 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2037 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT05692063 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults and children diagnosed with AAOCA without other congenital heart diseases.
✕Probably not a fit
Patients with other major congenital heart diseases or those with anomalous coronary artery origins from the pulmonary artery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to analyze clinical data and conduct computational simulations related to Anomalous Aortic Origin of the Coronary Artery (AAOCA). It includes a retrospective review of patients treated surgically and followed medically to identify risk factors for ischemia or sudden cardiac death. Additionally, there will be a prospective follow-up of enrolled patients to monitor for rare adverse events over time. The study will also involve retrieving morphological measurements from imaging studies and constructing a parametric model of the aortic root.
Why it matters
Potential benefit: If successful, this study could enhance understanding of AAOCA and improve patient outcomes by identifying risk factors and potential complications.
How similar studies have gone: While there may be studies on coronary artery anomalies, this specific approach combining clinical data analysis with computational modeling is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients (adults and pediatrics) who have been diagnosed with an anomalous aortic origin of any of the coronary arteries (AAOCA) without any other congenital heart disease and diagnosed/referred or followed at the IRCCS Policlinico San Donato. Exclusion Criteria: * Patients with other major congenital heart disease with associated coronary artery origin anomalies will be excluded. Patients with anomalous origin of the coronary artery from the pulmonary artery (ALCAPA or ARCAPA) will be excluded. Patients women who are pregnant.
Where it's running
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Irccs Policlinico San Donato
San Donato Milanese, Mi, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.