Understanding angiogenic function in normal term pregnancies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the angiogenic function of trophoblasts in placentas from healthy pregnancies at term. It aims to analyze the expression of pro- and antiangiogenic factors, such as placenta growth factor (PlGF) and soluble FMS-like tyrosine kinase-1 (sFlt-1), in human differentiated trophoblastic cells. The study will also explore the effects of various chemical compounds on placental functions and trophoblastic differentiation, potentially identifying therapeutic targets for pregnancy-related pathologies like pre-eclampsia and intrauterine growth restriction. By measuring gene and protein expression variations, the research seeks to enhance understanding of placental pathophysiology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnancies with scheduled cesarean delivery \>37 weeks of amenorrhea:
* strictly normal pregnancies
* complicated pregnancies of gestational diabetes, insulin-treated or not
* complicated pregnancies due to pregnancy cholestasis
* spontaneous or in vitro fecondation (IVF) / Intracytoplasmic sperm injection (ICSI) pregnancies with or without oocyte donation

Exclusion Criteria:

* Patient's opposition
* Age \< 18 years old
* Women under the protection of justice
* Multiple pregnancy
* Known major fetal malformation
* Pre-eclampsia and intrauterine growth retardation
* Placental insertionnomaly
* Type 1 diabetes
* HIV-positive patient with HIV/hepatisis C virus (HCV) regardless of viral load
* Patient in labour at the time of Caesarean section
* Patient whose medical history results in medication being taken in pregnancy courses that may interfere with the biology of the trophoblast (immunomodulators in case of autoimmune diseases, anti-rejection drugs in case of transplant patients)

Where it's running

• Centre Hospitalier Intercommunal de Créteil
  Créteil, France Recruiting

Study contacts

• Study coordinator: camille JUNG, MD
• Email: camille.jung@chicreteil.fr
• Phone: 00157022268

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.