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Understanding and treating neurological deficits after brain hemorrhage.

Late Neurological Ischemic Deficit in Patients Suffering From Subarachnoid Hemorrhage: Diagnosis and Treatment

Observational Fondazione IRCCS San Gerardo dei Tintori · NCT06804421

This study looks at how often people with brain bleeding from an aneurysm experience delayed neurological problems and aims to find better ways to treat them.

Quick facts

Study typeObservational
Enrollment1400 (estimated)
Ages18 Years and up
SexAll
SponsorFondazione IRCCS San Gerardo dei Tintori Academic / other
Locations33 sites (Bergamo, BG and 32 other locations)
Trial IDNCT06804421 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the incidence of delayed ischemic neurological deficits (DIND) in patients who have suffered from aneurysmal subarachnoid hemorrhage (aSAH). It will collect data on diagnostic imaging and clinical symptoms to better understand the occurrence and treatment of DIND, which is a significant cause of long-term disability in these patients. The study will involve patients aged 18 and older who have been diagnosed with aSAH and require intensive care. By identifying the incidence and characteristics of DIND, the study seeks to improve patient outcomes and treatment protocols.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with subarachnoid hemorrhage due to a ruptured cerebral artery aneurysm.

Not a fit: Patients under 18 years old or those with subarachnoid hemorrhage from non-aneurysmal causes will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for patients suffering from neurological deficits after aSAH.

How similar studies have performed: While the study addresses a significant gap in understanding DIND, similar studies have not yet established a gold standard for diagnosis or treatment, making this approach novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥ 18 years
* Primary diagnosis of subarachnoid hemorrhage due to rupture of a cerebral artery aneurysm confirmed by cerebral angiotomography or angiography of the intracranial vessels, with the need for admission to the Intensive Care Unit
* Signing the Informed Consent form to participate in the study according to current local regulations.

Exclusion Criteria:

* Age \< 18 years
* Primary diagnosis of subarachnoid hemorrhage sine materia, i.e. post-traumatic or caused by arteriovenous malformation or bleeding from a brain tumor.

Where this trial is running

Bergamo, BG and 32 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Aneurysmal Subarachnoid HaemorrhageDelayed Ischemic Neurological Deficit
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.