Understanding and treating neurological deficits after brain hemorrhage.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the incidence of delayed ischemic neurological deficits (DIND) in patients who have suffered from aneurysmal subarachnoid hemorrhage (aSAH). It will collect data on diagnostic imaging and clinical symptoms to better understand the occurrence and treatment of DIND, which is a significant cause of long-term disability in these patients. The study will involve patients aged 18 and older who have been diagnosed with aSAH and require intensive care. By identifying the incidence and characteristics of DIND, the study seeks to improve patient outcomes and treatment protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Primary diagnosis of subarachnoid hemorrhage due to rupture of a cerebral artery aneurysm confirmed by cerebral angiotomography or angiography of the intracranial vessels, with the need for admission to the Intensive Care Unit
* Signing the Informed Consent form to participate in the study according to current local regulations.

Exclusion Criteria:

* Age \< 18 years
* Primary diagnosis of subarachnoid hemorrhage sine materia, i.e. post-traumatic or caused by arteriovenous malformation or bleeding from a brain tumor.

Where it's running

• Fondazione IRCCS San Gerardo dei Tintori
  Monza, Mb, Italy Recruiting
• ASST Papa Giovanni XXIII
  Bergamo, Bg, Italy Not yet recruiting
• IRCCS Istituto delle Scienze Neurologiche
  Bologna, Bo, Italy Not yet recruiting
• ASST Spedali Civili
  Brescia, Bs, Italy Not yet recruiting
• Fondazione Poliambulanza
  Brescia, Bs, Italy Not yet recruiting
• ASST Lariana Ospedale Sant'Anna
  San Fermo della Battaglia, Co, Italy Not yet recruiting

Study contacts

• Principal investigator: Giuseppe Citerio, Professor, Head od Department — Fondazione IRCCS San Gerardo dei Tintori - Monza, Italy
• Study coordinator: Giuseppe Citerio, Professor, Head of Department
• Email: giuseppe.citerio@unimib.it
• Phone: +390392334316

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nitric Oxide Use to Predict Vasospasm in Aneurysmal Subarachnoid Hemorrhage

  This study tests whether nitric oxide consumption in CSF can predict cerebral vasospasm in patients with aneurysmal SAH.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07614906

• Multi-omics program to understand complications and outcomes after aneurysmal subarachnoid hemorrhage

  This project will test if combining blood, cerebrospinal fluid, urine, imaging, and multi-omics data can find biomarkers that predict complications and outcomes in adults with aneurysmal subarachnoid hemorrhage.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07270419

• Dome-only coiling for severe aneurysmal subarachnoid hemorrhage

  This will test a minimally invasive dome-protection coiling procedure to prevent re-bleeding in adults who have had a severe aneurysmal subarachnoid hemorrhage.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07250958

• Cilostazol to help prevent delayed brain ischemia after aneurysm bleed

  This study tests whether cilostazol can reduce delayed brain ischemia and improve outcomes after aneurysmal subarachnoid hemorrhage in adults who had recent aneurysm treatment.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07249853

• Transcutaneous Vagal Nerve Stimulation to help with brain vessel narrowing after aneurysm rupture

  This trial tests whether using a noninvasive nerve stimulation device can reduce cerebral vasospasm after an aneurysmal brain bleed in adults 18–65 who are undergoing standard treatment.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07131696

• Tocilizumab-aazg to reduce stroke risk after a ruptured brain aneurysm

  This trial will try to see if a single IV dose of tocilizumab-aazg is safe and can help prevent delayed strokes in adults who have had a ruptured brain aneurysm (aneurysmal subarachnoid hemorrhage).

  Recruiting Phase 1 University of Florida · Gainesville, Florida · NCT06863480

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.