Understanding airflow limitation in asthma exacerbations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the mechanisms behind expiratory airflow limitation in stable, non-smoking asthmatics with moderate to severe persistent airflow obstruction. Participants will receive inhaled corticosteroids and long-acting beta2-agonists while researchers assess whether large or small airways are primarily responsible for airflow limitation. The study will also evaluate the role of inflammation in these airways using exhaled nitric oxide as a marker. Additionally, lung function studies will be compared to pathological analyses from autopsy samples to better understand lung structure and function in asthma.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current non-smoking (\<10 pack yr smoking history)
* Stable, treated asthmatics
* Age 10-80 yr
* post 180ug albuterol by MDI: FEV 1/FVC \< 70% and FEV 1 \<80% predicted

Exclusion Criteria:

* Pregnancy

Where it's running

• Arthur F Gelb Medical Corporation
  Lakewood, California, United States Recruiting

Study contacts

• Principal investigator: Arthur F Gelb, MD — Arthur F Gelb Medical Corporation
• Study coordinator: Arthur F Gelb, MD
• Email: afgelb@msn.com
• Phone: 562-633-2204

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.