Ultrasound versus CT for measuring brain blood flow after subarachnoid hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study gives a licensed ultrasound contrast agent (SonoVue®) at the bedside and acquires contrast-enhanced ultrasound (CEUS) perfusion images through the temporal window, generating time–intensity curves to quantify cerebral perfusion. Those CEUS measurements are then compared with routine perfusion CT (CTP) performed for clinical indication to see how well the two methods agree. Participants are adult ICU/CCU patients who need at least one CTP, and patients who cannot consent may be enrolled with relative consent per local rules. Safety monitoring focuses on contrast agent tolerance and hemodynamic stability during and after imaging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient ≥ 18 years old
* Patient Informed Consent, or from his/her relative if the patient is not conscious and able to consent
* Admission to ICU or CCU with indication to perform at least one CTP
* Affiliated with or benefiting from a social security scheme
* The subject's current clinical status, as assessed by medical history, physical examination, and/or relevant tests, indicates that they do not require immediate medical treatment or emergency care at the time of enrolment.

Exclusion Criteria:

* Guardianship, curatorship or any deprivation of liberty by judicial or administrative decision
* Pregnant or breast-feeding women
* Known contra-indication or hypersensitivity to SonoVue® (to sulfur hexafluoride microbubbles or to one of its excipients such as polyethylene glycol (PEG))
* Right-to-left shunts
* Patients who have undergone craniectomy in the temporal region
* Patients with open wounds or recent scars in the temporal region
* Unstable hemodynamic or respiratory state contraindicating transportation to CTP scanner

Where it's running

• Centre Hospitalo-Universitaire Gui de Chauliac
  Montpellier, Herault, France Recruiting

Study contacts

• Study coordinator: Vivien Szabo, MD, PHD
• Email: v-szabo@chu-montpellier.fr
• Phone: +33467336733

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.