Ultrasound try to predict macrosomia at term
Official title: ECHO-MACRO : Ultrasound Estimation of Fetal Macrosomia at Term: Diagnostic Accuracy Within 24 Hours of Delivery
Run by Centre Hospitalier Henri Duffaut - Avignon · NCT07433751 · Data updated 2026-11-12
This study tests how well ultrasound weight estimates predict a baby’s birth weight in pregnancies with suspected macrosomia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 285 (estimated) |
| Sponsor | Centre Hospitalier Henri Duffaut - Avignon Academic / other |
| Locations | 1 site (Avignon) |
| Status | Recruiting |
| Started | April 8, 2026 |
| Main results expected | March 1, 2028 |
| Study ends | September 1, 2028 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07433751 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult pregnant people with singleton pregnancies, in the late third trimester, and suspected macrosomia based on Hadlock-derived estimates or diabetes status.
✕Probably not a fit
Pregnancies without suspected macrosomia or those with non-singleton gestations are unlikely to benefit from this testing approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study evaluates ultrasound-based fetal weight estimation at multiple points in the third trimester and before birth to see how accurately Hadlock-derived estimates match actual birth weight. The approach relies on standard biometric measurements taken during routine ultrasounds and uses established reference charts to flag potential macrosomia. Pregnant individuals with singleton pregnancies and suspected macrosomia are enrolled and followed to delivery to compare estimated weights with actual birth outcomes. The study aims to identify the accuracy window within 24 hours of delivery and to inform clinical decisions around delivery planning. Safety considerations center on the standard use of ultrasound without introducing new procedures.
Why it matters
Potential benefit: If successful, the approach could improve decision-making around timing and mode of delivery for pregnancies with suspected fetal overgrowth.
How similar studies have gone: Previous studies show that ultrasound-based fetal weight estimates have a reasonable margin of error but are useful for guiding clinical decisions; this trial evaluates accuracy within 24 hours of birth in a specific high-suspicion population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years old. * Patient with suspected fetal macrosomia above the 95th percentile, or above the 90th percentile in the case of maternal diabetes, according to Hadlock's formula and WHO charts, during the third-trimester ultrasound (between 32 and 34 weeks of amenorrhea). * Female patient presenting for a follow-up ultrasound at 36 ± 1 weeks of amenorrhea due to suspected macrosomia. * Singleton pregnancy. Exclusion Criteria: * Fetal weight estimation at 36 ± 1 weeks of amenorrhea and macrosomia assessment performed outside of the hospital. * Patient with uncertain gestational age. * Patient with a multiple pregnancy * Presence of detectable morphological or chromosomal abnormalities.
Where it's running
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Centre Hospitalier d'Avignon, Hôpital Henri Duffaut
Avignon, France Recruiting
Study contacts
- Study coordinator: Marilyne Grinand, PhD
- Email: grinand.marilyne@ch-avignon.fr
- Phone: (+33)432759392
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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AI ultrasound tool to estimate fetal weight before delivery
A AI-enabled ultrasound test is being tried in 1,000 pregnant people to see how accurately it can predict fetal weight compared with standard specialist measurements.
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AI feedback on fetal weight estimates across clinician experience levels
A real-time AI help is tested to see if it makes fetal weight estimates from ultrasound more accurate, especially for novices and intermediates, compared with doing it manually.
-
Heart risk check for young women 3–6 years after pregnancy with or without placental complications.
This project will test an app-based algorithm to see if it can identify cardiovascular risk in women 3–6 years after giving birth, including those who had preeclampsia or low-birth-weight infants.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.