Ultrasound Muscle Imaging to Screen for Muscle Atrophy in Fetuses at Risk of AMC
Official title: Technical Feasibility Study of Ultrasound Muscle Imaging in Antenatal Ultrasound Screening of Congenital Multiple Arthrogryposis
Run by University Hospital, Grenoble · NCT06130592 · Data updated 2026-11-12
This study tests a new ultrasound method to look at muscle tissue during mid-pregnancy to see if it can help screen fetuses for muscle problems in pregnancies at risk for Arthrogryposis Multiplex Congenita.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | Women only |
| Enrollment | 230 (estimated) |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 2 sites (La Tronche, Isère and 1 other locations) |
| Status | Recruiting |
| Started | May 12, 2024 |
| Main results expected | November 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT06130592 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant women between 21 and 24 weeks gestation, singleton pregnancies, evaluated at Lyon or Grenoble prenatal centers, with consent.
✕Probably not a fit
Pregnant women with multiple pregnancies, BMI over 30 in early pregnancy, or those not meeting other criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an interventional study evaluating a specialized ultrasound technique to image fetal muscles during 21-24 weeks of gestation. The goal is to determine how feasible it is to perform four extremity muscle scans and specific tissue measurements in both low-risk and high-risk pregnancies suspected of AMC. The study focuses on pregnancy cohorts in Lyon and Grenoble, enrolling mono-zygotic pregnancies with regulatory consent. Primary endpoints center on the completion rate of the four extremity muscle sections and quantitative measurements between skin, fascia, and muscle layers. The approach addresses limitations of routine antenatal ultrasound for detecting AMC-related muscle atrophy.
Why it matters
Potential benefit: If successful, this technique could improve early detection of fetal muscle problems associated with AMC, informing planning and care.
How similar studies have gone: Prior approaches have shown limited sensitivity; this study tests a focused ultrasound method in AMC contexts and is relatively novel in this antenatal setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any pregnant woman consulting in one of the two obstetric gynecology departments in connection with the CPDPN (Multidisciplinary Prenatal Diagnostic Centers) of the University hospitals of Lyon or Grenoble. * Mono-embryonic pregnancy. * Gestational ages retained on the first dating ultrasound or the 1st trimester ultrasound between 21-24 amenorrhea weeks. * For women at "high risk": diagnosis during ultrasound of the 1st, 2nd, or 3rd trimesters, of an abnormality of position / deformation of one or more joints, and / or an abnormality of fetal movements on screening ultrasound or interrogation (population group at "high risk of AMC"). * Regulatory criteria: adults, affiliated to a social security scheme, having signed a consent Exclusion Criteria: * Multiple pregnancies, and / or non-progressive . * Obese women (BMI \> 30 in early pregnancy) * Subject in a period of exclusion from another study * Subject under administrative or judicial supervision * Subject who cannot be contacted in case of emergency
Where it's running
-
university hospital of Grenoble
La Tronche, Isère, France Recruiting -
Hopitaux Civils de Lyon - Hôpital Femme Mère Enfant
Bron, Rhone, France Recruiting
Study contacts
- Principal investigator: Klaus DIETERICH, MD,PhD — Univ. Grenoble Alpes Inserm U1209 IAB CHU Grenoble Alpes
- Study coordinator: Lora PEJOT, Midwife
- Email: lpejot@chu-grenoble.fr
- Phone: 0476766561
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.