Ultrasound microbubble imaging to detect kidney damage in children and teens with acute lymphoblastic leukemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use ultrasound localization microscopy (ULM) with a microbubble contrast agent together with blood samples and urine analysis to image kidney microvasculature in children and adolescents aged 3 to under 18 with acute lymphoblastic leukemia. Participants may be survivors who have completed treatment or patients within 50 days of therapy start who have not yet received cyclophosphamide. The protocol combines noninvasive imaging for microvascular changes with laboratory markers such as albuminuria, an early sign of kidney damage, to detect acute and chronic nephrotoxicity. Patients with known clinically evident renal impairment or contraindications to the contrast agent are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed acute lymphatic leukemia
* From 3 years to \< 18 years
* completed oncological treatment or treatment day \< 50 according to therapy protocol and no administration of CPM before first examination.

Exclusion Criteria:

* Known allergic disposition to SonoVue / other contrast agents
* Tattoo in the area of the examination field
* Pregnancy
* Breastfeeding mothers
* Contraindication for the use of Sonovue
* Critical condition
* Known clinically evident renal impairment

Where it's running

• Department of Pediatrics and Adolescent Medicine
  Erlangen, Baveria, Germany Recruiting

Study contacts

• Study coordinator: Axel Karow, MD
• Email: axel.karow@uk-erlangen.de
• Phone: +4991318533118

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.